Learning abilities 392 INDEX

The final portion of the GLP surveiUance inspection includes examination of records and reports as described under Parts 58.185, 58.190, and 58.195. To accomphsh this, FDA assesses the fachitys ability to store and retrieve study data, reports, specimens, and so on in a manner that maximizes their integrity and utihty. This must include an overview of how the firm maintains materials such as the raw data and the various specimens that are developed in the course of the study. The investigators must become famihar with the facility s archives regarding their location and accessibility. The individuals responsible for the archives must be identified and FDA must learn whether or not the archive is indexed and if the materials and records that have been transferred and stored elsewhere are appropriately identified. Furthermore, the procedures for adding or removing materials from the archives must be examined and individual test systems are selected randomly to determine that all raw data, specimens, and documents have been retained as required. 

A set of 160 barbiturates was coded using 46 molecular descriptors, including fragments, substructures, environmental descriptors, and a molecular connectivity index C287, 288, 2921. Classifiers were developed with a learning machine that recognizes the duration of the depressant effect- Predictive abilities of 94 % were reported for correct classifications of the duration time "less than t minutes". 

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