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Antitargets

Localization/Expression Function/Pathophysiology Target (Desired Effect) Antitarget (Side Effect)... [Pg.56]

All agents so far identified as torsadogenic have been shown to block the hERG K+ channels, which are undoubtedly the primary antitarget when exploring the QT liability of a compound. [Pg.59]

GPCR Antitarget Modeling Pharmacophore Models to Avoid GPCR-Mediated Side Effects... [Pg.127]

Table 6.1 Biogenic amine binding GPCR antitargets and side effects mediated by high-affinity agonists and antagonists of the respective receptor. ... Table 6.1 Biogenic amine binding GPCR antitargets and side effects mediated by high-affinity agonists and antagonists of the respective receptor. ...
GPCR Antitarget Pharmacophore Modeling The ana Adrenergic Receptor... [Pg.130]

Validation of Antitarget Pharmacophore Models 6.3.3.1 Virtual Screening Hit Rates and Yields... [Pg.132]

Scheme 6.1 Chemical structures of adrenergic receptor antagonists for generation of antitarget pharmacophores class I (a) and class II (b). Scheme 6.1 Chemical structures of adrenergic receptor antagonists for generation of antitarget pharmacophores class I (a) and class II (b).
CPCR Antitarget Pharmacophore Modeling The aIo Adrenergic Receptor 135... [Pg.135]

The main application of the generated antitarget pharmacophore hypotheses is to rationalize these experimental findings by providing pharmacophore-based... [Pg.138]

The Emergence of Serotonin 5-HT2B Receptors as Drug Antitargets... [Pg.143]

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See also in sourсe #XX -- [ Pg.346 , Pg.350 ]

See also in sourсe #XX -- [ Pg.338 ]



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ABC Transporters - From Targets to Antitargets

Antitarget

Antitarget

Antitarget Pharmacophore Models

Antitarget activity models

Antitarget and ADME(T) Screening Using Pharmacophores

Antitarget screening

Antitargets prediction

Lead optimization antitarget activity

Target and Antitarget Pharmacophore Modeling

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