Lead explosive

The enzymes that participate in blood clotting also are activated by partial proteolysis, which again serves to keep them in check until they are needed. The blood coagulation system involves a cascade of at least seven serine proteases, each of which activates the subsequent enzyme in the series (fig. 9.2). Because each molecule of activated enzyme can, in turn, activate many molecules of the next enzyme, initiation of the process by factors that are exposed in damaged tissue leads explosively to the conversion of prothrombin to thrombin, the final serine protease in the series. Thrombin then cuts another protein, fibrin, into peptides that stick together to form a clot. 

Lead explosion where a lead or leads are followed up by an analoguing experiment designed to probe the neighboring (bioisosteric) property space with the intention of finding active analogues and detecting structure-activity trends. 

The lead explosion process works by comparing the structures of the lead compounds with those in ChemSpace followed by compiling a list of ChemSpace... 

Figure 5. A depiction of lead explosion where Optiverse compounds (stars) are supplemented by structurally similar ChemSpace structures (diamonds).

Since a lead explosion program involves a much more intensive examination of a localized area of property space of established relevance, it gives one a better... 

Lead explosion and other directed synthesis methods may uncover better compounds, but these may not be the best. Further lead refinement may be necessary, more likely using chemistries that are less amenable to high-throughput methods, to design compounds which will enhance the properties still further. This activity still lies firmly in the domain of conventional medicinal chemistry. 

One of the leading explosives factories in Europe. Vihtavuori Works in Finland, has developed a modern process for the manufacture of primers after the explosion in 1961 [180]. The main novelty being remote control. 

It is not altogether surprising to learn that in 1909 both Nathan and Rintoul, the leading explosives technologists of their time, left government service to become General Manager and Chief Chemist, respectively, of the Nobel s Explosives Company at Ardeer, Scotland. At Ardeer the manufacture of NG and NG were well established and there is every indication that the newcomers were most welcome and set a new course... 

Precaution Corrosive to iron, steel, brass, copper, lead explosive reaction with ethyl vinyl ether incompat. with hydrogen fluoride, alkalis, amines, vinyl ethers reacts violently with water Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of SO,... 

Booster and lead explosives are compounds and formulations that are used to transmit and augment the detonation reaction. They are typically used in the beginning stage of an explosive train, for example, in a Fuze. 

---