Lead compounds computer-assisted drug design

An example of a leading chemical CRO is Albany Molecular (AMRI). It had chemistry revenues 184 million in 2005. AMRI does organic synthesis and chemistry development, supported by computational chemistry for molecular modeling, with computer-assisted drug design. Furthermore, it offers different types of libraries custom, semiexclusive, focused, and natural products. Finally, AMRI conducts its own proprietary R D aimed at licensing preclinical and clinical compounds. 

The processes as just described do not require any information coordination between the genomics and proteomics work and the subsequent lead discovery and optimization. In the last decade, there has been a growing effort to transition the information from the proteomics step into a computer-aided dmg discovery process—to use the information about the protein itself to help choose appropriate compounds to screen for the desired efficacy. The use of computers to assist in drug discovery neither is new nor was always tied to the use of protein structures. The recent developments in proteomics have focused the work on protein structure-based computer-aided drug design. 

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