Latent autoimmune diabetes in adults

Markers of autoimmunity have been detected in 14% to 33% of persons with type 2 DM in some populations and manifest with early failure of oral agents and insulin dependence. This type of DM has also been referred to as latent autoimmune diabetes in adults (LADA)." ... 

Goodpasture disease glutathione- S -transferase indirect immunofluorescence latent autoimmune diabetes in adults... 

Leslie RD, Williams R, PozziUi P. Clinical review Type 1 diabetes and latent autoimmune diabetes in adults one end of the rainbow. J Clin Endocrinol Metab 2006 91(5) 1654-1659. 

Individuals with type 2 diabetes may not require insulin to survive, but 30% or more will benefit from insulin therapy to control blood glucose. It is likely that 10-20% of individuals in whom type 2 diabetes was initially diagnosed actually have both type 1 and type 2 or a slowly progressing type 1 called latent autoimmune diabetes of adults (LADA), and they will ultimately require full insulin replacement. Although persons with type 2 diabetes ordinarily... 

Autoantibody markers of immune destruction are present in 85% to 90% of individuals with immune-mediated diabetes when fasting hyperglycemia is initially detected. Approximately 10% to 12% of white adult patients who have the type 2 diabetes phenotype also have islet cell auto antibodies, particularly to GADgs. This condition has been termed latent autoimmune diabetes of adulthood (LADA). Up to 1% to 2% of healthy individuals have a single autoantibody and are at low risk of developing immune-mediated diabetes. Because the prevalence of immune-mediated diabetes is low (-0.3% in the general... 

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