Lasiodiplodia theobromae

In 1978 Givaudan patented a transformation of a-ionone [127] a fermentation of Botryodiplodia theobromae IFO 6469 with a-ionone (152) yielded a mixture of compounds (155 -157) with honeysuckle aroma, Fig. (31). The same fungi which efficiently biotransformed / -ionone also transformed a-ionone [128]. As observed for /1-ionone, a-ionone (152) transformations with Lasiodiplodia theobromae ATCC 28570 also suggested an oxygenase-type enzyme system to be responsible for the degradation of the molecule by loss of one C2-unit. 

Lasiodiplodia theobromae is a rare opportunistic human pathogen causing keratitis, onycho- and phaeohyphomycosis [80]. Botryosphaeria rhodina is known as a teleomorph of L. theobromae. B. rhodina clusters with B. ribis (fig. 3.) in the Dothideales [247]. 

The culture filtrates of the organism Lasiodiplodia theobromae afforded a plant growth inhibitor which was identified as lasiodiplodin (90) after structural studies. From a retrosynthetic viewpoint, construction of the aromatic residue of 90 (a resorcinol ester) lends itself quite nicely to methodology involving addition of an acetoacetate moiety to a functionalized olefin. Different variants of this strategy are employed in the following syntheses of 90. 

Recently, ten cytochalasin compounds were isolated from yet another unidentified Phomopsis fungus. Six of these metabolites were shown to have novel structures and they were given the trivial names cytochalasins N (27), O (28), P (29), Q (30), R (31) and S (32).The remaining four compounds were identified as the known epoxycytochalasins H and J (33, 34), and cytochalasins H and J (25, 26). In addition, the compounds trans- and c/s-(3S,4S)-4-hydroxymellein, were also isolated from the same extract the latter Is a known fungal metabolite of Lasiodiplodia theobromae and the genus Cercospora. ... 

Aldridge DC, Galt S, Giles D, Turner WB (1971) Metabolites of Lasiodiplodia theobromae. 1 Chem Soc 1623... 

Lasiodiplodia theobromae Fungi SMKY, EtOH, 7 days, 28°C S50 Ranasinghe et al. (2002)... 

Several studies claimed traditional Asian medicinal plants may provide a fertile source for drug discovery. Gangadevi and Muthumary isolated a series of Taxol-producing fungi from medicinal plants [72-75]. Pandi et al. [76] found Taxol in the fermentation broth of an endophytic fungus, Lasiodiplodia theobromae, which was isolated from the leaves of Morinda citrifolia, a medicinal plant. 

Pandi M, Kumaran RS, Choi YK, Kim HJ, Muthumary J (2011) Isolation and detectirm of taxol, an anticancer dmg produced from Lasiodiplodia theobromae, an endophytic fungus of the medicinal plant Morinda citrifolia. Afr J Biotechnol 10 1428-1435... 

Metab. of Lasiodiplodia theobromae and the marine algae Undaria pinnatifida and Botryocladia leptopoda. Mp 210-218° (198-200°). 

Lasiodiplodia theobromae Lederle culture Z1640 Lenzites subferuginea Lenzites thermophylla... 

Diplodia gossipina ATCC 16391 -Lasiodiplodia theobromae MF5215... 

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