Laser tissue ablation

Class IV UV cutting laser for rapid outlining and removal of large areas of tissue (see Table 1), or (3) UV laser for ablation, by photo volatilization, of unwanted or contaminating tissue (see Note 17). The software navigation tools are similar to the AutoPix therefore, only the UV cutting laser procedure will be described in detail for the Veritas instrument. 

The Ho YAG (HolmiumiYAG) laser, emitting pulses of 2.1 pm wavelength and up to 4 J in energy, used in soft tissue ablation in arthroscopic (joint) surgery (FDA approved). 

Furthermore, to analyze biological tissues of plants or thin sections of human brain tissues or ice cores, cooled laser ablation chambers have been developed and utilized in different application... 

Figure 6.23 Experimental arrangement of solution based calibration using a micronebulizer (DS-5, CETAC) inserted in a cooled laser ablation chamber for imaging of thin sections of brain tissue. (/. S. Becker et ai, Anal. Chem. 77, 3208 (2005). Reproduced by permission of American Chemical Society.)...

R Keenan, M. Cooke, and J. Appleton, Trace Element Profiting of Dental Tissues Using Laser Ablation Inductively Coupled Plasma-Mass Spectrometry Fresenius J. Anal. Chem. 1996, 354.254.]... 

Ablation can be carried out with lower cost laser diodes when a broadband energy absorber is applied to the skin. For example, shallow pores are created by application of twenty to thirty 20 ms pulses of 810 nm radiation at a power of250 mW to a 50 pm thick carbon containing black tape on the skin.50 A pattern of these shallow pores is easily generated on the skin by movement of the laser. Application of about one-half atmosphere of vacuum extracts about 0.2 pL ISF per minute with a relative standard deviation of 65%, which includes person-to-person and site-to-site variabilities. Larger volumes of ISF ( 0.5 pL/min) can be exuded from the ablated site by application of positive pressure to the tissue around the site. In general, the volume exuded increases as the number of micropores at the site increases from one to... 

Nemes P, Barton A, Li Y, Vertes A (2008) Ambient molecular imaging and depth profiling of live tissue by infrared laser ablation electrospray ionization mass spectrometry. Anal Chem 80 4575 1582. doi 10.1021/ac8004082... 

Nemes P, Woods A, Vertes A (2010) Simultaneous imaging of small metabolites and lipids in rat brain tissue at atmospheric pressure by laser ablation electrospray ionization mass spectrometry. Anal Chem 82 982-988. doi 10.1021/ac902245p... 

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