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Larock indole synthesis Mechanism

The scope and mechanism of palladium-catalyzed annulation of internal alkynes to give 2,3-disubstituted indoles, the effect of substituents on the aniline nitrogen or on the alkynes, as well as the effect of the salts such as LiCl or n-BuaNCl were studied by Larock and coworkers (1998 JOC7652). The mechanism they propose for indole synthesis proceeds as follows (a) reduction of the Pd(OAc)2 to Pd(0) (b) coordination of the chloride to form a chloride-Ugated zerovalent palladium species (c) oxidative addition of the aryl iodide to Pd(0) (d) coordination of the alkyne to the... [Pg.3]

See other pages where Larock indole synthesis Mechanism is mentioned: [Pg.28]    [Pg.225]    [Pg.25]    [Pg.123]    [Pg.29]    [Pg.144]    [Pg.27]    [Pg.241]   
See also in sourсe #XX -- [ Pg.3 ]

See also in sourсe #XX -- [ Pg.611 ]



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