Lactic acid Corynebacterium glutamicum

Amino acids, citric acid, lactic acid, propanediol, penicillin G, synthetic drug intermediates, and therapeutic proteins are among the industrially relevant products of fermentation and cell culture that have been targets for metabolic engineering. Some ofthis work has been adopted by industry (see [72], section 16.4.1). The major aim was to optimize the yields of industrial products, which was efficiently realized with Corynebacterium glutamicum for lysine and tryptophan, and at the Dupont company for 1,3-propane diol production [107-109]. 

Okino, S, Suda, M., Fujikura, K, Inui, M., and Yukawa, H. (2008) Production of D-lactic acid by Corynebacterium glutamicum under oxygen deprivation. Appl. Microbiol. Biotechnol, 78 (3), 449-454. 

Barrett E, Stanton C, Zelder O, Fitzgerald G, Ross RP. (2004). Heterologous expression of lactose- and galactose-utilizing pathways from lactic acid bacteria in Corynebacterium glutamicum for production of lysine in whey. Appl Environ Microbiol, 70, 2861-2866. 

An array of industrially important microorganisms is needed in order to efficiently convert green biomass into useful products such as lactic acid, l-lysine and ethanol using the concept of green biorefining. The most important microbes have been identified in this book chapter as Lactobacillus salivarius, Corynebacterium glutamicum and Saccharomyces cerevisiae. 

---