Lactation topiramate

Lactation Topiramate is excreted in the milk of lactating rats. Limited observations in patients suggest an extensive secretion of topiramate into breast milk. Weigh the potential benefit to the mother against the potential risk to the infant. 

The concentrations of topiramate have been measured in plasma and breast milk in five women with epilepsy during pregnancy and lactation (52). The umbilical cord plasma/maternal plasma ratios were close to unity, suggesting extensive transplacental transfer of topiramate. The mean milk/maternal plasma concentration ratio was 0.86 (range 0.67-1.1) at 2-3 weeks after delivery. The milk/maternal plasma concentration ratios at sampling 1 and 3 months after delivery were similar. Two of the breast-fed infants had detectable (>0.9 pmol/l) concentrations of topiramate 2-3 weeks after delivery, although they were below the limit of quantification (2.8 pmol/l), and one had an undetectable concentration. Thus, breastfed infants had very low topiramate concentrations. No adverse effects were observed in the infants. 

Topiramate kinetics during delivery, lactation, and in the neonate preliminary observations. Epilepsia... 

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See also in sourсe #XX -- [ ]

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