Lactam carboxymethyl

In conclusion, the results of our study indicate that the principal features of the formation of poly (2,6-dioxo-l,4-piperidinediyl) trimethylene by thermal polymerization of / -carboxymethyl caprolactam consists in an initial isomerization of the caprolactam derivative to a reactive species and subsequent polymerization of the latter by condensation. The reactive intermediate is in all probability either or both the 3-(3-aminopropyl)-glutaranhydride or its linear dimer. Both the conversion of the lactam by isomerization and the polycondensation follow second-order kinetics. 

Cyclic amines react with diethyl oxalate to form bi-and tricyclic amides, e.g., (62) and (63), while l,8-bis(carboxymethyl)-cyclam forms the intramolecular tricyclic lactam (64).62... 

N-Carboxymethyl-derivat dee Lactams der 3- Amino-1.2.2-trimetby l-cy clopen tan carbons nre.(l) 211 277- ... 

Branched-chain Sugars. - 5-C-Methyl-a L-idopyranose, 6-deoxy-7-C-(2-furyl)-l,2 3,4-di-0-isopropylidene-L-gtycero-a-D-galacto-htptopyranose, tert-butyl 4-C-aminomethyl 3-C-carboxymethyl-2,3,4-trideoxy-a-D-fyxo-hexopyranoside-5-lactam, the 3-C-substituted 3-deoxy-a-D-altroside (20), methyl 4,6-0-benzylidene-2-0-(4-bromobenzoyl)-3-C-(3-methyl-... 

The a-carboxymethyl caprolactam was obtained from a-bromo-caprolactam via nucleophilic substitution employing sodium diethyl malonate (3), whereas both 3-carboxymethyl caprolactam uid 4-carboxymethyl-2-piperldone were synthesized via nucleophilic addition of the malonate euiibne to the corresponding a, 3 unsaturated lactam (4,S). The 4-carboxy-methyl-2-pyrrolidone was obtained by hydrolysis of the corresponding ethyl ester which was synthesized according to the procedures given by Henecka et al. (6.S). 

Con arlng the structures of the lactams listed In Table 2 with those of their corresponding reaction products Indicates that the conversion of the former entails isomerization processes. In case of the g-carboxymethyl capro-lactcun, the Isomerization could be... 

AT-Carboxymethyl dipeptides are obtained by using the Strecker reaction between the amino-group of a dipeptide and an aldehyde. Chiral P-lactam components are used in a synthesis of the pentapeptide enkephalin analogue L-Tyr-D-Ala-Gly-L-Phe-L-Leu. ... 

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