Labeling of Proteins with Organometallic Complexes Strategies and Applications

Labeling of Proteins with Organometallic Complexes Strategies and Applications 

The first example of reaction of a half sandwich metallocene with a protein was reported a few years later. Tetramethylcyclobutadiene nickel(II) dichloride 2 was shown to react with the enzyme horse hver alcohol dehydrogenase to afford a modified enzyme devoid of zinc and enzymatic activity and containing 8 mol nickel per mol protein. The mode of binding of this organometallic complex had not been fully elucidated at that time but was thought to occur by substitution of the chloride ligands by nucleophilic residues [3], 

The versatile chemistry of transition organometallic complexes, their proven biological stability and their sometimes unique physical properties have since 

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Salmain, M. Labeling of Proteins with Organometallic Complexes Strategies and Applications. In Bioorganometallics-, Jaouen, G., Ed. ... 

Labeling of Proteins with Organometallic Complexes Strategies and Applications 6.2.2... 

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