L-tyrosine hydrochloride

LTYRHC10. L-Tyrosine hydrochloride (neutron study) (CgH NO, Cl-). Frey MN, Koetzle TF, Lehmann MS, Hamilton WC (1973) J Chem Phys 58 2547 LTYROS11. L-Tyrosine (neutron study) (C NO. Frey MN, Koetzle TF, Lehmann MS, Hamilton WC (1973) J Chem Phys 58 2547... 

D. W. Smits and E. H. Wicbenga. Acta Cryst. 6, 531-9 (1953). x-ray crystal structure of glycyl-L-tyrosine hydrochloride. 

L-Tyrosine hydrochloride L-Cysteine methyl ester hydrochloride Quinuclidine hydrochloride p-Dichlorobenzene... 

L-glutamic acid hydrochloride, as determined through fits of the static and MAS spectra, done using the DMFIT program. In addition, the authors reconfirmed the values obtained previously for L-tyrosine hydrochloride. While no experimental CSA data were reported, first principles calculations were done, predicting small CS tensor spans ranging between 78 and 157 ppm. ... 

Fig. 19. C spectra of L-tyrosine hydrochloride powder at a rotor frequency of 1.03 kHz. Top ID MAS spectrum (3888 transients). Bottom 2D-PASS spectrum showing sidebands separated in the loi dimension. The toj slices are labelled with the order of the sidebands, A . Sixteen tj increments were taken, each the sum of 243 transients. (Reproduced from Antzutkin et with permission.)...

A methanolic soln. of methyl L-tyrosinate hydrochloride and triethylamine added to a stirred soln. of methyl 2-0-acetyl-4,6-0-benzylidene-3-deoxy-3-nitro-/5-gluco-pyranoside, and allowed to stand 4 hrs. at room temp. methyl N-(methyl 4,6-0-benzylidene-2,3-dideoxy-3-nitro- -D-glucopyranosid-2-yl)-L-tyrosinate. Y 78%. F. e. s. F. J. M. Rajabalee, Synthesis 1972, 318 carbohydrate 1,2-nitramines, without triethylamine, s. Carbohyd. Res. 26, 219 (1973). 

A mixture was made of L-tyrosine (18.1 g, 0.1 mol) benzoyl chloride (7.0 g, 0.05 mol) and 200 ml anhydrous THF. After stirring at reflux for 2 hours, the mixture was cooled to room temperature, and the precipitate of tyrosine hydrochloride filtered off (11 g, 46 meq. Cr). The THF was evaporated and the residue extracted with CCI4 (3 X 100 ml at reflux, discarded) and then dissolved in ethyl acetate (200 ml) filtering off insolubles. The ethyl acetate solution was evaporated to yield 13.2 g solid product, MP 159°-162°C (93%). The tyrosine was recovered (8 g) by neutralization with aqueous alkali, from the hydrochloride. 

S,N-Ditrityl-L-cysteine diethylamine selt L-Tyrosine lower alkyl ester L-lsoleucine lower alkyl ester Benzyl-L-proline hydrochloride L-Leucine lower alkyl ester Ammonia Hydrogen chloride Glycine lower alkyl ester... 

L-Cysteine hydrochloride (H2O) [52-89-1] M 157.6, m 175-178° (dec), [0] +6.53° (5M HCl). Likely impurities are cystine and tyrosine. Crystd from MeOH by adding ethyl ether, or from hot 20% HCl. Dried under vacuum over P2O5. Hygroscopic. 

Similarly, (S)-fi-tyrosine hydrochloride is prepared by addition of the lithium amide of N-[(R)-l-phenylethyl]benzylamine to methyl ( )-3-[(4-benzyloxy)phenyl]-2-propenoate and subsequent hydrogenolysis and saponification24. Recently, a number of publications concerning related work has appeared139-146. The reaction of lithiated, mono-silylated 1-phenylethyl-amines with a-enones has also been studied130131. 

Thioxo-l,3,6-thiadiazocin-5-ones (36) are conveniently prepared from a-amino acid ester hydrochlorides in one pot by sequential treatment with carbon disulfide, followed by 2-bromoethylamine hydrobromide (Scheme 28) <90SC2675>. Starting with L-tyrosine leads to an optically active thia-diazocine indicating that racemization does not occur during the reaction. 

Tolazoline hydrochloride Tolbutamide T riacetyloleandomycin Trihexyphenidyl base Trihexyphenidyl hydrochloride Trimethaphancamphorsulfonate T ripelennamine Tripelennamine citrate Tripelennamine hydrochloride L-Tryptophan Tubocurarine chloride L-Tyrosine Tyrothricin... 

C9H9NO3, Hippuric acid, 37B, 273 38B, 494 40B, 448 CgHgNaOy H2O, 3,5-Dinitro-L"tyrosine monohydrate, 45B, 5l8 C9H11CIN2O4, DL-p-Nitrophenylalanine hydrochloride, 44B, 436 C9H11NO3, DL-Tyrosine, 39B, 356 C9H11NO3, L-Tyrosine, 38B, 495 39B, 357 C9H11NO3, 2-Hydroxyphenylalanine (o-Tyrosine), 41B, 542... 

Many patents have been issued on the use of pyrogaUol derivatives as pharmaceuticals. PyrogaUol has been used extemaUy in the form of an ointment or a solution in the treatment of skin diseases, eg, psoriasis, ringworm, and lupus erythematosus. GaUamine triethiodide (16) is an important muscle relaxant in surgery it also is used in convulsive-shock therapy. Trimethoprim (2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine) is an antimicrobial and is a component of Bactrin and Septra. Trimetazidine (l(2,3,4-trimethoxybenzyl)piperazine (Vastarel, Yosimilon) is used as a coronary vasodilator. l,2,3,4-Tetrahydro-6-methoxy-l-(3,4,5-trimethoxyphenyl)-9JT-pyrido[3,4- ]indole hydrochloride is useful as a tranquilizer (52) (see Hypnotics, sedatives, ANTICONVULSANTS, AND ANXIOLYTICS). Substituted indanones made from pyrogaUol trimethyl ether depress the central nervous system (CNS) (53). Tyrosine-and glycine(2,3,4-trihydroxybenzyl)hydrazides are characterized by antidepressant and anti-Parkinson activity (54). 

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