L-Palmitoyl-2-oleoylphosphatidylcholine

Hydrolysis of Lipids Name the products of mild hydrolysis with dilute NaOH of (a) l-stearoyl-2,3-dipalmitoyl-glycerol (b) l-palmitoyl-2-oleoylphosphatidylcholine. 

The lipids in a lipid bilayer may translocate across the bilayer from one monolayer to the apposed monolayer. This transmembrane translocation process, which is also known as flip-flop, is slow for lipids with large polar head groups such as glyc-erolipids and sphingophospholipids but can be fast in the case of lipids with very small polar moieties such as cholesterol. Typical first-order rate constants for transmembrane translocation of a phospholipid-like molecule in liquid-disordered phase bilayers prepared from l-palmitoyl-2-oleoylphosphatidylcholine (POPC) are s and may be about 10-fold slower in... 

Koster, K., Webb, M., Bryant, G., and Lynch, D. Interaction between soluble sugars and POPC (l-palmitoyl-2-oleoylphosphatidylcholine) during dehydration Vitrification of sugars alters the phase behavior, Biochim. Biophys. Acta, 1193, 143,1994. 

Plate 16. The lipid pocket of apo B. Apo B22.5 is represented with P-strands shown as green arrows and a-helices shown as turquoise tubes. l-Palmitoyl-2-oleoylphosphatidylcholine (POPC) is shown with carbon atoms in gray and oxygens in red. There are 34 POPC molecules in the large opening and 14 POPC molecules in the small opening. Thus, a total of 48 POPC molecules fit into the lipid pocket. From Ref. [24], with permission. (See page 511 in this volume.)... 

Fig. 8. Lateral phase separation in an equimolar mixture of dipalmitoyl and l-palmitoyl-2-oleoylphosphatidylcholine, as measured by differential scanning calorimetry and visualized by freezefracturing after quenching from a temperature between the two thermotropic peaks. From (97).

Deuterium NMR spectra at different temperature ranging from — 75 to - -10°C were obtained from fully H20-hydrated POPC (l-palmitoyl-2-oleoylphosphatidylcholine) multilamellar vesicles (MLVs), prepared with and without cholesterol, to determine the freezing temperature of water and the effect of cholesterol on the freezing temperature of water in POPC bilayers. P NMR data suggest that lipid bilayers can be aligned at low temperatures, while N NMR experiments demonstrate that such aligned samples can be used to enhance the signal-to-noise ratio of N chem. shift spectra of a 37-residue human antimicrobial peptide, LL-37. ... 

---