L-Nicotine

Figure 2.28. Sequence of measurements to determine the spin-lattice relaxation times of the C nuclei of the pyridine ring in L-nicotine (46) [(CD3)2CO, 75 % v/v, 25 °C, inversion-recovery sequence, 20 MHz], The times at which signals pass through zero have been used to calculate, by equation 10, the T, values for the pyridine C atoms in L-nicotine...

Drew, A.E., Derbez, A.E., and Werling, L.L., Nicotinic receptor-mediated regulation of transporter activity in the rat prefrontal cortex, Synapse, 38, 10, 2000. 

Meshul, C.K., Kamel, D., Moore, C., Kay, T.S., Krentz, L. Nicotine alters striatal glutamate function and decreases the apomorphine-induced contralateral rotations in 6-OHDA-lesioned rats. Exp. Neurol. 175 257, 2002. 

Figure 15. L-ornithine and L-nicotinic acids are precursors of some aikaioids in the Nightshade famiiy.

Jones, S., Sudweeks, S., Yakel, J. L. Nicotinic receptors in the brain correlating physiology with function, Trends Neurosci. 1999, 22, 555-561. 

Molecular imprinting has been used to devise a chemosensor for L-nicotine (Table 6) [178]. For that, poly(methacrylic acid) (PMA) beads, imprinted with the L-nicotine template in chloroform, were incorporated in a film of the conjugated polymer, OCiC10-PPV. EIS has then been utilized for the L-nicotine determination in the 1-10 nM concentration range. This MIP chemosensor showed predominant affinity towards L-nicotine over a structurally related L-nicotine metabolite, L-cotinine. Similarly, the polydopamine-imprinted film prepared by electropolymerization in the phosphate buffer (pH = 7.4) has been used to devise a chemosensor for L-nicotine with LOD of 0.5 pM (Table 6) [106]. This LOD is still much higher than that reported for other L-nicotine determination methods based on MIPs, such as SPE combined with differential pulsed elution, which was 6 nM [31]. 

SYNS CHLORHYDRATE de NICOTINE (FRENCH) NICOTINE HYDROCHLORIDE (d,l) NICOTINE HYDROCHLORIDE, soludon (DOT)... 

Jaimes EA, Tian RX, Raij L. Nicotine The link between cigarette smoking and the progression of renal injury Am J Physiol Heart Circ Physiol 2007 292(1) H76-82. 

Fig. 3-66. Separation of monovalent anions using nicotinic acid as the eluent. — Separator column Wescan 269-031 eluent 0.01 moI/L nicotinic acid flow rate 2.7 mL/min detection direct conductivity injection volume 100 pL solute concentrations 20 ppm azide, 10 ppm formate and fluoride, 20 ppm orthophosphate, 10 ppm nitrite and chloride, 15 ppm bromate (taken from [70]).

Grady, S.R., Grun, E.U., Marks, M.J., Collins, A.C., 1997. Pharmacological comparison of transient and persistent [ H]dopamine release from mouse striatal synaptosomes and response to chronic L-nicotine treatment. J. Pharmacol. Exp. Ther. 282, 32-43. 

Schmeltz, L Nicotine and other tobacco alkaloids in Naturally occurring insecticides, edited by M. Jacobson and D.G. Crosby, Marcel Dekker, New York, NY (1971) pp. 99-136. 

Stedman, R.L Nicotine reduction in tobacco smoke in Toward a less harmful cigarette, edited by E.L. Wynder and D. Hoffmann, Natl. Cancer Inst. Monograph 28 (1968) 113-119. 

Leurosine, 20-21 Leusine, 427-429 Levoprox)q>hene, 228—229 Lignans, 103—106 Lincangenine, 26—27 Lindenianine, 145 Liriodenine, 53-54, 208 Littorine, 31-32, 145 L-lysine-derived alkaloids, 109 L-lysine-derived nuclei, 108-109,108/ L-lysine into (-/lupinine, 133 L-nicotinic acids, 31-32, 33/... 

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