L- alcohols

If tile high boiling residue is transferred to a small Claisen flask and distilled, some n-hexj l alcohol passes over first, followed by n-hexyl n-caproate (2 g.) at 240-250° (mainly 245°). 

The undermentioned reductions may be carried out by simple adaptations to the procedures chloral to trichloroethj 1 alcohol m-nltroacetophenone of a-methyl-3-nitrobenzyl alcohol and o-nitrobenzaldehyde to o-nitroben l alcohol. 

At blood levels from 0.4g%-0.6g% (86.8 to 130.2 mmol/L) alcoholic coma often occurs, accompanied by decreased respiration, blood pressure, and body temperature Blood levels between 0.6 g% and 0.8 g% (130.2 to 173.6 mmol/L) are often fatal resulting from respiratory arrest, aspiration of gastric contents, or airway obstruction due to flaccid tongue... 

The rate constants are given in Table 1 for reactions under the following conditions 0.1-0.6 mol/L siloxane, 4 mol/L alcohol, 0.002-0.006 mol/L HCIO4, 0.05 mol/L H20 in dioxane. Also in Table 1 are given the equilibrium constants, determined for the same reaction series. 

Buervenich S, Sydow O, Carmine A, Zhang Z, Anvret M, Olson L. Alcohol dehydrogenase alleles in Parkinson s disease. Mov Disord 2000 15 813-818. 

Solubility Insoluble in water, soluble in acetic acid and alkali 61.4 g/L water, 769 g/L alcohol, 500 g/L glycerol Soluble in water, slightly soluble in alcohol... 

With a view to increasing the selectivity in OZT formation (i.e. reducing the number of products shown in Scheme 23), selective hydroxyl protections were performed. Protection of the C-l alcohol would induce limitation to fused structures (Scheme 25),10 whereas 3-O-protection would only allow formation of s/hro-derivatives (Scheme 26).47... 

Medici et al. have used a combined sequential oxidation-reduction to access a range of imsaturated secondary alcohols from their racemates [7] (Scheme 1). Here the S-alcohol 2 is oxidized by B. stereothermophilus which is displaying Prelog specificity leaving the l -enantiomer untouched. The other microorganism, Y. lipolytica contains an anti-Prelog dehydrogenase which is therefore able to reduce the ketone 1 to the l -alcohol 2. Thus the combination of the two steps effects a net deracemization of substrate 2. 

At constant T and p, for a two-component system (say, water(l) + alcohol(2)), we thus obtain the classical Gibbs adsorption equation as... 

Thus in the series of reactions on the optically active(-l-) alcohol... 

More than two-thirds of the benzyl chloride produced is used in the manufacture of butyl benzy l phthalate, a plasticizer used extensively in vinyl flooring and other flexible poly(vinyl chloride) uses such as food packaging. Other significant uses are the manufacture of benzy l alcohol and benzyl chloride-derived quaternary ammonium compounds, each of which consumes more than 10% of the benzyl chloride produced. In the dye industry, benzyl chloride is used as an intermediate in the manufacture of triphenyl-methane dyes. Derivatives of benzyl chloride are processed further to pharmaceutical, perfume and flavour products (Lin Bieron, 1993). 

In rats receiving [ Cjbenzyl chloride in corn oil by gavage, the peak plasma level was reached after 30 min. The distribution half-life was 1.3 h, while the elimination half-life was 58.5 h. After 48 h, the higher concentrations were found in the stomach, gastric contents, ileum and duodenum, followed by liver, adrenal, bone marrow and blood. After 72 h, approximately 76% was excreted in urine and, in expired air, 7% as 002 and less than 1.3% as benzyl chloride or its metabolites. Urinary metabolites were identified as Y-benzyl-A-acetyl cysteine, benzx l alcohol and benzaldehyde (Saxena Abdel-Rahman, 1989). 

Anil[noprop/l Alcohol. See Anilinopropanol y-Anilinopropyleneglycol. See 3-Anilino-l,2-propanedol or l-Ani ino-2,3-propandiol... 

The bromide was prepared from the cyclopropyl earblnol obtained by reduction and fxotu the halide a Grignard compound was formed. This/compound treated with formaldehyds gave among other products cydobutylcarblspl.8 Whether this is to be attributed to isomerization or to the presence of cyclobutanol in the cycloprop>l alcohol is uncertain. 

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