L-Alaninamide

S-(1 R, 2S, 3R )]-A/-(4-morpholinyl-sulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-/ /-[1-cyclohexylmethyl-2,3-dihydroxy-5-methylhexyl]-L-alaninamide)... 

A-Acetyl-L-alaninamide [15962-47-7] M 130.2, m 162". Crystd repeatedly from EtOH-diethyl ether. 

A-Acetyl-L-alanyl-L-alanyl-L-alaninamide [29428-34-0] M 272.3, m 295-300 . Crystd from MeOH/diethyl ether. 

Fig. 7-6). Two unichiral amides which have been known capable of this reaction are 1-phenylethylamine [15] and l-(l-naphthyl)ethylamine [16]. Marfey s reagent [N-a-(2,4-dinitro-5-fluorophenyl)-L-alaninamide] was introduced as a reagent to deriva-tize amino acids with cyclopentane, tetrahydroisoquinoline or tetraline structures [17]. Simple chiral alcohols such as 2-octanol can also be used to derivatize acids such as 2-chloro-3-phenylmethoxypropionic acid [18]. 

CN L-Alanyl-W-[(la,5a,6a)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-l,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-L-alaninamide monomethanesulfonate... 

Direct and indirect chromatographic methods were developed and compared in systematic examinations for the enantioseparation of P-amino acids direct separation of underivatized analytes involved the use of commercially available Crownpak CR(-I-), teicoplanin, and ristocetin A CSPs [148], while indirect separation was based on precolumn derivatization with 2,3,4,6-tetra-G-acetyl-f)-D-glucopyranosyl isothiocyanate (GITC) or A - a-(2,4-dinitro-5-fluorophenyl)-L-alaninamide (EDAA, Marfey s reagent), with subsequent separation on a nonenantioselective column. 

IV-Acetyl-L-alanyl-L-alaninamide [30802-37-0] M 201.2, m 250-251°. Crystd repeatedly from EtOH/ethyl ether. 

V-Benzyloxycarbonyl-V-methyl-L-alaninamide [33628-84-1 ] M 236.3. Recrystd from ethyl acetate. 

A-Benzyloxycarbonylglycyl-L-alaninamide [ 17331-79-2] M 279.3. Recrystd from EtOH/ethyl ether. 

Methyl (5)-2-[[2-(Benzyloxycarbonylamino)propanoyl]an]ino]-3-oxobntanoate (32) 1 1 A soln of methyl 2-diazo-3-oxobutanoate (1.0g, 7.0mmol) in dry CHCI3 was added dropwise over 6h to a boiling soln of A -(benzyloxycarbonyl)-L-alaninamide (31 1.11 g, 5 mmol) and Rh(OAc)2 (2mol%) in EtOH-free CHC13. The mixture was refluxed for a further 30 min, allowed to cool, concentrated and purified by column chromatography (silica gel, EtOAc/petroleum ether 1 1) to afford 32 as an inseparable mixture of diastereomers yield 1.19g (71%) mp 122-123°C (colorless needles, EtOAc/petroleum ether). 

Chemical Name N-Carboxy-p-alanyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide N-tert-butylester... 

V-Acetylglycyl-L-alaninamide [34017-20-4] M 175.2. Repeated crystn from EtOH/Et20. Dried in a vacuum desiccator over KOH. 

A-Acetyl-L-alaninamide [15962-47-7] M 130.2, m 162 . Crystallise the amide repeatedly from EtOH/diethyl ether. The ( )-isomer crystallises from H2O and has m 157-158°. [Greenstein Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1838 1961. de Jong Reel Trav Chim Pays-Bas 19 288 1900, Fischer Otto Chem Ber 36 2106 1903, Beilstein 4 H 295.]... 

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