Fischer, Otto

A-Acetyl-L-alaninamide [15962-47-7] M 130.2, m 162 . Crystallise the amide repeatedly from EtOH/diethyl ether. The ( )-isomer crystallises from H2O and has m 157-158°. [Greenstein Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1838 1961. de Jong Reel Trav Chim Pays-Bas 19 288 1900, Fischer Otto Chem Ber 36 2106 1903, Beilstein 4 H 295.]... 

The first triaryknethane dyes were synthesized on a strictiy empirical basis in the late 1850s an example is fuchsine, which was prepared from the reaction of vinyl chloride with aniline. Thek stmctural relationship to triphenylmethane was estabHshed by Otto and Fmil Fischer (5) with the identification of pararosaniline [569-61-9] as 4,4, 4 -triaminotriphenyknethane and the stmctural elucidation of fuchsine. Several different stmctures have been assigned to the triaryknethane dyes (6—8), but none accounts precisely for the observed spectral characteristics. The triaryknethane dyes are therefore generally considered to be resonance hybrids. However, for convenience, usually only one hybrid is indicated, as shown for crystal violet [548-62-9] Cl Basic Violet 3 (1), for which = 589 nm. 

The hydroformylation reaction was discovered by Otto Roelen in 1938 (2,3) while investigating the influence of olefins on the Fischer-Tropsch reaction (/). Particularly in commercial publications, it has been termed the oxo reaction the more proper term, hydroformylation, was proposed by Adkins (4). 

Peripheral vasodilation can precipitate a fall in blood pressure. Intravenous injection of male Fischer 344 rats with PGDN at 0.1 to 30 mg/kg produced a dose-related fall in systolic blood pressure within 1 min (Godin et al. 1995). No drop in blood pressure in rats was observed over a 30-45 min period during exposure to an atmosphere of saturated PGDN vapor (82-90 ppm) generated from Otto Fuel II (Godin et al. 1993). 

E Fischer, E Otto. Synthesis of derivatives of some dipeptides. Ber Deutsch Chem... 

Zuckermann et al.[216 217 have adapted the method developed by Fischer and Otto[268 for a convenient synthesis of peptoids and peptoid-peptide hybrids by SPPS. The peptoid monomer is built on the solid support by first preparing a bromoacetyl submonomer and then substituting the bromine with an alkyl- or side-chain-protected co-functional alkylamine (Scheme 41, route B). 

Smith, F. See also, Jones, J. K. N. Sowden, John C., The Nitromethane and 2-Nitroethanol Syntheses, 8, 291-318 Sowden, John C., [Obituary of] Hermann Otto Laurenz Fischer, 17, 1-14 Sowden, John C., The Saccharinic Acids, 12, 35-79... 

FISCHER, ERNST OTTO (I9I8-). A German inorganic chemist who won the Nobel prize lor chemistry in 1973 with Geoffrey Wilkinson for their independent work on the chemistry of organomctallic "sandwich compounds. He was the contributor to many publications on organiimeiallic ehemislry. His education and work were primarily in Munich. 

WILKINSON, GEOFFREY (1921-1996). A British organic chemist who won the Nobel prize for chemistry in 1973 with F,rnst Otto Fischer, for their pioneering work, performed independently, on the chemistry of the org an o metal lie. so called sandwich compounds. He was a professor at the University of California and Harvard before returning as professor of inorganic chemistry at the University of London. 

Hydroformylation is a precious metal-catalyzed reaction of synthesis gas, a 1 1 mixture of hydrogen and carbon monoxide, and an olefinic organic compound to form aldehydes. The reaction was discovered by Otto Roelen in 1938 in experiments for the Fischer-Tropsch reaction [8]. In Scheme 3, hydroformylation of a terminal olefin is shown in which the addition of carbon monoxide can be conducted at both carbon atoms of the double bond, thus yielding linear (n) and branched (iso) aldehydes. 

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