KSHV genome

Sequence analysis of the 145 kh KSHV genome revealed one ORF, ORF74, with the hallmark of a chemokine receptor and three ORFs, K6, K4 and K4.1, encoding the chemokines vCCLl, vCCL2 and vCd.3 respectively. vCCL2 is unique in the chemokine system because it binds to and antagonizes receptors from all of the four chemokine receptor subfamilies (CC, CXC, XC and Besides having sprecific pro- and/or anti- chemotactic properties, all... 

Indirecte oncogenic herpesviruses EBV and KSHV. EBV. Some protein products of herpes viral genomic segments (EBV) encounter c-Myc proteins, form host cell and viral protein complexes, thus inducing immune reactions to host cell proteins via the phenomenon of molecular mimicry, so claim Niller et al [925, 926]. 

Alone among known human herpesviruses, KSHV has two ORFs whose deduced amino acid sequences are similar to human CC chemokines, with highest similarity to MlP-la and RANTES (13,16,63,78). The names given to the encoded proteins are vMlP-I (ORF K6) and vMIP-II (ORF K4) which have 37.9% and 41.1% amino acid identity to MlP-la, respectively. vMIP-I and vMIP-II are 48% identical in amino acid sequence. These relationships suggest that vMIP-I and vMIP-II evolved by gene duplication rather than by independent acquisition from the host genome. A third KSHV ORF (K4.1) is also related to the CC chemokine family, but this gene is more distantly related and probably derived independently. Both vMlP-1 and VMIP-II are expressed in latently infected lymphoma cells, and their expression is induced by phorbol esters (63). 

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