Krebs cycle definition

The urea cycle, also called ornithine cycle, was first described by H.A. Krebs and K. Henseleit in 1932. (quot. 51) The principle of ammonia detoxification in the urea cycle is based on the conversion of ammonium and bicarbonate in the mitochondria under ATP consumption into carbamoyl phosphate (by means of carbamoyl phosphate synthetase). It enters the urea cycle, which is localized mainly - yet with a low affinity for ammonium - in the periportal zone of the liver lobule. In the urea cycle alone, about two thirds of the amino nitrogen of ammonia are irretrievably lost to the organism (= definitive ammonia detoxification), (s. fig. 3.12)... 

As far as the 1953 selection of the Nobel Prize winners for science is concerned, one could look at this event as a perfect stage management of the Nobel Committee. The Nobel Prize for Medicine and Physiology went to Hans Krebs for the Citric acid cycle and enzymatic reactions , to Fritz Lipmann for Coenzyme A , and the Nobel Prize for Chemistry to Hermann Staudinger [7, p. 1064]. In addition, Watson and Crick had just rang in molecular biology definitely with their Nature article on their DNA model [18]. 

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