Knowledge design strategy

Knowledge-based Combinatorial Library Design Strategies I 155... 

G. Klebe, Utilising structural knowledge in drug design strategies applications using Relibase, /. Mol. Biol. 2003, 326, 621-636. 

Jacoby, E. (2001) A novel chemogenomics knowledge-based ligand design strategy -application to G protein-coupled receptors. Quant. Struct.-Act. Relat.20, 115-123. 

The focus of this chapter will be on introducing novel knowledge-based strategies for designing chemical libraries directed to the family of nuclear receptors, with special emphasis on more generic, often overlooked aspects such as the degree of expected family coverage and bias by the compounds in the library. As extensively... 

Figure 3.22 The penicillin molecule interferes with the action of bacteria (and therefore of infections) by mimicking the structure of D-ala-D-ala involved in the production of bacterial cell walls in cell division. This is a rationalisation after the event, namely the discovery of the action of penicillin by chance by Alexander Fleming. By contrast modern rational drug design strategies involve using the knowledge of the structure of receptor sites. From Helliwell (1977b) reproduced with permission of New Scientist.

Site-directed Mutagenesis One final technique, most closely related to the structure-based drug design strategy, that can contribute knowledge to aU these... 

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