Kinetics of Drug Absorption after Oral Administration

KINETICS OF DRUG ABSORPTION AFTER ORAL ADMINISTRATION 

FIGURE 4.8 The processes of drug absorption and disposition (distribution and elimination) interact to generate the observed time course of drug in the body. Similarly, the output function can be represented as an interaction betw een absorption and disposition functions. 

FIGURE 4.9 Disposition model representing the elimination of a unit impulse drug dose (Hq = 1) from a single body compartment. Drug in this compartment (H) is removed as specified by the first-order elimination rate constant k. 

FIGURE 4.10 Model representing the absorption of a drug dose (Mq) from a gut compartment to a plasma compartment. The first-order absorption constant a determines the rate at which drug remaining in the gut (M) is transferred to plasma (X). 

The table of inverse Laplace transforms shows that there are two solutions for this equation. Usually, a k and 

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