Cascades, kinase signaling

Li H, Wong WS. Pertussis toxin activates tyrosine kinase signaling cascade in myelomonocytic cells a mechanism for cell adhesion. Biochem Biophys Res Commun 2001 283(5) 1077-1082. 

Chang L, Karin M (2001) Mammalian MAP kinase signalling cascades. Nature 410(6824) 37-40 Chen Y, Hashiguchi N, Yip L, Junger WG (2006) Hypertonic saline enhances neutrophil elastase release through activation of P2 and A receptors. Am J Physiol Cell Physiol 290(4) C1051-C1059... 

Chang L, Karin M. 2001. Mammalian MAP kinase signaling cascades. Nature. 410 37-40. 

Antibodies directed against (32 -GPI further enrich the protein on the cell surface but these promote a p38 Map-kinase signalling cascade which results in increased expression of tissue factor (TF) and reduced expression of thrombomodulin on the surface of cells. TF is a major initiator of coagulation and increased levels of TF expression have been measured on endothelial cells treated with anti-phospholipid antibodies and on monocytes both ex vivo and in vivo (Yasuda et al., 2005 Lopez-lira et al., 2005, Lopez-Pedrera et al., 2006). Thrombomodulin is a potent anti-coagulant protein which limits activation of thrombin, so the net result of circulating anti-phospholipid antibodies is to usurp the anti-coagulative, protective mechanism and initiate a pro-coagulation cascade. 

Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol CellBiol25, 3670-3681. 

Chang, L., and Karin, M. (2001). Mammalian MAP kinase signalling cascades. Nature 410,37-40. 

Perez O, Krutzik P, Nolan G. Flow cytometric analysis of kinase signaling cascades. Meth Mol Biol 2004 263 67-94. 

Having introduced Ras, the master switch of the MAP kinase (mitogen-activated protein kinase) signalling cascades, we are now ready to put the pieces of the puzzle together and sum up the essential features of a typical cellular signalling pathway, the Ras/MAP kinase... 

Benn J., Schneider R. J. (1994) Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc. Natl. Acad. Sci. USA 91 10350. 

Abraham ST, Benscoter HA, Schworer CM, Singer HA (1997) A role for Ca /calmodulin-dependent protein kinase II in the mitogen-activated protein kinase signaling cascade of cultured rat aortic vascular smooth muscle cells. Circ Res 81 575-584... 

Mandal, C., A. Dutta, A. Mallick, et al. 2008. Withaferin A induces apxjptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin tiuough mitochondrial death cascade. Apoptosis 13 (12) 1450-1464. 

Perkinton MS, Sihra TS, Williams RJ. Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phospha-tidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons. J Neurosci 1999 19(14) 5861-5874. 

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