Kidney tumors clear-cell

SETD2 represses transcription, and as such, it may function as a tumor suppressor gene. The polybromo gene product SET domain protein (PBRMl) protects cells against mutational induction (loss of VHL gene) of kidney carcinoma, clear cell subtype [1929-1933]. )... 

Ribalta T, Lloreta J, Munne A, et al. Malignant pigmented clear cell epithelioid tumor of the kidney clear cell ( sugar ) tumor versus malignant melanoma. Hum Pathol. 2000 31 516-519. 

Clear Cell Sarcoma of the Kidney 443 Rhahdoid Tumor of the Kidney 443 Juvenile Renal Cell Carcinoma 445 Renal Medullary Carcinoma 446 Malignant Hematologic Diseases 446 Peripheral Primitive Neuroectodermal Tumor 446 Metastases 447... 

Argani P, Perlman EJ, Breslow NE et al (2000) Clear cell sarcoma of the kidney a review of 351 cases from the National Wilms Tumor Study Group Pathology Center. Am J Surg Pathol 24(1) 4-18... 

In 2 year gavage studies, there was clear evidence of carcinogenic activity of D-limonene for male rats, as shown by increased incidences of tubular cell hyperplasia, adenomas, and adenocarcinomas of the kidney. There was no evidence of carcinogenic activity of D-limonene for female rats. There was no evidence of carcinogenic activity of D-limonene for male or female mice. The nephrotoxicity of D-limonene was studied in rats and mice. Kidney sections taken from male rats that had been part of a 91 day oral dosing study of limonene in rats and mice were examined by light microscopy. The study showed that renal alterations were induced only in male rats. As discussed above, the mechanism by which D-limonene caused the tumors in male rats is irrelevant to humans. 

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