7-Glutamyl transpeptidase kidney

Cramer, S. C., et al. Colocalization of GLUT2 glucose transporter, sodium/ glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocyto-chemistry. Diabetes 1992, 43, 766—770. 

NT263 Anand, C. V., U. Anand, and R. Agarwal. Anti-oxidant enzymes, gamma-glutamyl transpeptidase and lipid peroxidation in kidney of rats exposed to cigarette smoke. Indian J Exp Biol 1996 34(5) 486-488. 

In contrast to y-glutamyl transpeptidase, which is almost entirely bound to particulates, y-glutamyl cyclotransferase is present in the supernatant fractions of liver and other tissues. Studies on the distribution of the enzyme shows that it is present in most animal tissues but that there are some species differences (Table IV). Relatively high enzymic activity is found in kidney, liver, brain, and skin. In man, the highest activity is found in the brain. The unusually high activity in... 

The albumin-degrading light subunit of rat kidney y-glutamyl transpeptidase... 

Attempts have been made to develop noninvasive tests that might provide more specific information about the site of injury. For example, excretion of enzymes in urine may reflect renal injury. Urinary excretion of enzymes of renal origin (enzymes that are specific to the kidney, such as maltase, y-glutamyl transpeptidase, or treha-lase) could indicate specific destruction of renal proximal tubules, whereas alkaline phosphatase in urine could arise from renal or prerenal (e.g., hepatic) damage (Figure 29.7). 

Other Enzymes Involved In Mercapturlc Acid Btosynthesls. These enzymes have not been as extensively studied m fish as the GSH-S-transferases. Gamma glutamyl transpeptidase activity has been demonstrated In kidney and Intestinal caeca but not liver of the rainbow trout ( ), and In kidney, but not liver, red blood cells, brain or... 

The D -glutamyl strategy for confining drug action to the kidney and the urinary tract requires that the prodrug under consideration can function as a substrate for -glutamyl transpeptidase and, eventually, for A -acylamino acid deacylase. 

S-alkyl cysteines, such as S-allyl cysteine (SAC), S-methyl cysteine (SMC), and S-propyl cysteines are slowly formed during sprouting from the action of y-glutamyl transpeptidase on y-glutamyl cysteines. S-allyl cysteine is also rapidly formed in the body by hydrolysis of y-glutamyl cysteine particularly in the kidney which contains an abundant amount of Y-glutamyl transpeptidase activity [2]. 

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