Ki-67 labeling index

Dardes, R. D. C. M., Horiguchi, J., and Jordan, V. C. 2000. A pilot study of the effects of short term tamoxifen therapy on Ki-67 labeling index in women with primary breast cancer, hit. J. Oncol. 7(5 25-30. 

Mastronardi, L., Guiducci, A., Spera, C., Puzzilli, F., Liberati., and Maira, G. 1999. Ki-67 labelling index and invasiveness among anterior pituitary adenomas Analysis of 103 cases using the MIB-1 monoclonal antibody./. Clin. Pathol. 52 107-111. 

Thompson et al. (2005) reported that tumor cell proliferation and c-erbB2 expression decreased by 34% and 71%, respectively, whereas cell apoptosis increased (31%) in menopausal women fed a diet containing 25 g of flaxseed. Changes in c-erbB2 score and apoptosis index were correlated with total flaxseed intake whereas cell proliferation, as measured by Ki-67 labeling index, was not. A main conclusion from these studies was that the lignans and, to a lesser extent, ALA were responsible for the anticarcinogenic activity. 

The third patient was a 70-year-old man whose transbronchial biopsy showed a uniform population of cells with focal crush artifact but no necrosis or mitotic activity. The neoplastic cells showed no immunostaining for TTF-1 but showed intense immunostaining for chromogranin A and synaptophysin. The Ki-67 labeling index was less than 20%. 

Ki-67 labeling index is an important part of grading and classification of PENs. 

Margulis V, Lotan Y, Karakiewicz PI, et al. Multi-institutional validation of the predictive value of Ki-67 labeling index in patients with urinary bladder cancer. / Natl Cancer Inst. 2009 101 114. 

Shih IM, Kurman RJ. Ki-67 labeling index in the diffetential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma A double immunohistochemi-cal staining technique using Ki-67 and Mel-CAM antibodies. Hum Pathol. 1998 29 27-33. 

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