Khorana studies

Khorana et al. 233) also carried out a sequence of bacteriorhodopsin, which was largely in agreement with the earlier study but which found another tryptophan residue... 

This conclusion has been drawn by Moffatt and Khorana,2 based on limited data. A subsequent, more detailed study [R. K. Ledneva, N. N. Preobrazhenskaya, Z. A. Shabarova, and M. A. Prokof ev, Molek. Biologiya, 5, 264 (1971)] clearly shows an unexpected decrease in the rate of the acid hydrolysis of the phosphor-amidates derived from strong amines. If a similar order of reactivities exists for the pyrophosphate synthesis, the phosphomorpholidate derivative seems close to being the most active. 

Fig. 2. Proposed structural requirements for substrates of phosphodiesterases that hydrolyze DNA and RNA, those from (a) snake venom, (b) spleen, and (c) staphylococcus (R = thymine and R — p-nitrophenyl). The studies indicated for the venom and spleen enzymes are those suggested by Khorana (67) [data from Cuatrecasas el al. (61)).

Altenbach, C., Cai, K., Khorana, H. G., and Hubbell, W. L. (1999a). Structural features and light-dependent changes in the sequence 306-322 extending from helix VII to the palmitoylation sites in rhodopsin A site-directed spin-labeling study. Biochemistry 38, 7931-7937. 

Z. T. Farahbakhsh, K. D. Ridge, H. G. Khorana, and W. L. Hubbell. Mapping light-dependent structural changes in the cytoplasmic loop connecting helices C and D in rhodopsin a site-directed spin labeling study. Biochemistry, 34, 8812-8819, 1995. 

Altenbach C, Flitsch SL, Khorana HG, Hubbell WL (1989) Structural studies on transmembrane proteins. 2. Spin labeling of bacteriorhodopsin mutants at unique cysteines. Biochemistry 28 7806-7812... 

Khorana, H. G. 1968 Nucleic acid synthesis in the study of Genetic code. Nobel Lecture 341-366. 

Har Gobind Khorana was bom in a small village in British India, in which his family was among the few fiterate residents. He received his M.S. ftom the University of Lahore, and in 1945 he was awarded a grant to study for... 

Khorana, J. Am. Chem. Soc. 86, 4188 0964), X-ray analysis studies of orthorhombic lorm Alver, Furberg, Acta... 

Stephen G. Withers (B.Sc. and Ph.D.) was trained at the University of Bristol, UK, where he obtained his Ph.D. under the supervision of Dr. Michael Sinnott. Later he moved to Canada as a postdoctoral fellow, applying heteronuclear NMR to the study of enzymatic catalysis with Drs. Brian Sykes and Neil Madsen in the Department of Biochemistry at the University of Alberta. In 1982 he moved to the University of British Columbia as assistant professor of chemistry. He now holds the Khorana Chair of Chemistry and Biochemistry at UBC and serves as the director of CHiBi, the Centre for High-throughput Biology at UBC. 

Smith M, Rammler DH, Goldberg IH, Khorana HG. Studies on polynucleotides. Specific synthesis of the C3 -C5 interribonucleotide linkage. J Am Chem Soc 84 430-440, 1962. 

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