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Khorana

In the diester method a deoxynucleoside-5 -monophosphate is condensed with the 3 -OH group of a deoxynucleotide to produce a 3, 5 -phosphodiester. This is illustrated by a general method for dinucleotide synthesis developed by H.G. Khorana (K.L. Agarwal, 1976). One N-... [Pg.216]

These were originally prepared by Khorana as selective protective groups for the 5 -OH of nucleosides and nucleotides. They were designed to be more acid-labile than the trityl group because depurination is often a problem in the acid-catalyzed removal of the trityl group. Introduction of p-methoxy groups increases the rate of hydrolysis by about one order of magnitude for each p-methoxy substituent. For 5 -protected uridine derivatives in 80% AcOH, 20°, the time for hydrolysis was... [Pg.62]

H. Gobind Khorana (medicine) interpretations of the genetic code and its function in protein synthesis... [Pg.6]

See other pages where Khorana is mentioned: [Pg.63]    [Pg.159]    [Pg.361]    [Pg.379]    [Pg.18]    [Pg.364]    [Pg.83]    [Pg.67]    [Pg.67]    [Pg.91]    [Pg.114]    [Pg.115]    [Pg.131]    [Pg.133]    [Pg.134]    [Pg.279]    [Pg.394]    [Pg.522]    [Pg.94]    [Pg.311]    [Pg.105]    [Pg.111]    [Pg.157]    [Pg.193]    [Pg.195]    [Pg.222]    [Pg.226]    [Pg.227]    [Pg.457]    [Pg.627]    [Pg.681]    [Pg.681]    [Pg.699]    [Pg.100]    [Pg.101]    [Pg.101]    [Pg.101]    [Pg.53]    [Pg.787]    [Pg.126]    [Pg.617]    [Pg.620]    [Pg.1799]    [Pg.107]    [Pg.123]    [Pg.130]    [Pg.130]    [Pg.130]   
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Khorana studies

Khorana, H. Gobind

Khorana, Har Gobind

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