Synthesis dinucleotide

In the diester method a deoxynucleoside-5 -monophosphate is condensed with the 3 -OH group of a deoxynucleotide to produce a 3, 5 -phosphodiester. This is illustrated by a general method for dinucleotide synthesis developed by H.G. Khorana (K.L. Agarwal, 1976). One N-... 

P-NMR spectroscopic studies on the reaction course of the dinucleotide synthesis from 3 -0-acetylthymidine 5 -phosphate (pT-Ac) (180a) and 5 -0-trityl-thymidine (Tr-T) in the presence of triisopropylbenzenesulfonyl chloride (TPS) confirm the metaphosphate hypothesis 123,124). Successive addition of 0.5 equiv. 

Carba-Nicotinamide Adenine Dinucleotide Synthesis and Enzymological Application of a Novel Inhibitor of ADP-ribosyl Transfer... 

Barile, M., Passarella, S., Bertoldi, A., and Quagliariello, E., 1993. Flavin adenine dinucleotide synthesis in isolated rat liver mitochondria caused by imported flavin mononucleotide. Archives of Biochemistry and Biophysics. 

Pyridine dinucleotide, synthesis of analogs, 252, 253 Pyridine nucleotide analogs, 260 spin-labeled, 260... 

DNA Sequencing and Synthesis CHAPTER 26 Dinucleotide Synthesis Deprotection, Coupling, and Oxidation... 

Working with the Concepts Exploring Mechanistic Features of Solid-Phase Dinucleotide Synthesis... 

In the dinucleotide synthesis on page 1209, the attachment of the first nucleoside to silica employs a 4-nitrophenyl ester as a leaving group. Why would the use of this substituent be advantageous ... 

An apparatus for continuous-flow solution-phase reactions has been described (68) combining a flow reactor with a solvent extraction, continuous evaporation, and liquid chromatography system. A scheme for the use of this apparatus in dinucleotide synthesis has been proposed (46), but applications to the preparation of longer oligonucleotides have not been reported. 

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