Syrups ketotifen

Take 1.5 L of purified water and heat to 90° to 95°C, allow to cool down to 30°C, and bubble with nitrogen gas. Keep for batch preparation. 

Dissolve the parabens in 1 L in a separate vessel and stir until the solution is completely clear. Add citric acid, disodium hydrogen phosphate anhydrous, sucrose, and sorbitol and stir slowly 

In a separate container dissolve ketotifen hydrogen fumarate in ethanol until clear. 

Add the alcoholic mixture slowly to the syrup while stirring at room temperature avoiding entrapment of air. 

Pass the syrup through 100-mesh screen and then through filter press until sparkling clear. 

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Zaditen syrup contains ketotifen, an antihistamine that may cause drowsiness. Patients are therefore advised not to drive or operate machinery. 

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