Ketorolac Nonsteroidal anti-inflammatory drugs

Four-arm hydrogel hydrogen containing nonsteroidal anti-inflammatory drug (NSAID) compositions were prepared by Burton et al. (2) and used to deliver Ketorolac , (I). 

Clinical use Ketorolac (Gillis and Brogden, 1997) is a nonsteroidal anti-inflammatory drug mainly used for the treatment of moderate to severe postoperative pain. 

Various nonsteroidal anti-inflammatory drugs (NSAIDs) have been studied for potential clinical use in allergic conjunctivitis. Specifically, ketorolac tromethamine 0.5% has been found to be beneficial in treating SAC and is currently the only NSAID approved for topical treatment of SAC. 

Topical nonsteroidal anti-inflammatory drugs (NSAIDs), such as bromfenac, diclofenac, ketorolac, and nepafenac, have been advocated, but there is evidence that commercially available preparations do not appear effective in treating episcleritis. Topical flurbiprofen and ketorolac were foimd to be no more effective than placebo in treating episcleritis therefore, treatment modalities other than topical NSAIDs should be used. 

Menniti-Ippolito F, Maggini M, Raschetti R, Da Cas R, Traversa G, Walker AM. Ketorolac use in outpatients and gastrointestinal hospitalization a comparison with other nonsteroidal anti-inflammatory drugs in Italy. Eur J Clin Pharmacol 1998 54(5) 393-7. 

Ketorolac (Toradol), a nonsteroidal anti-inflammatory drug. 

Kim SY, Kim EM, Nam K-H, Chang DJ, Nam SH, Kim KJ. Postoperative intravenous patient-controlled analgesia in thyroid surgery comparison of fentanyl and ondansetron regimens with and without the nonsteroidal anti-inflammatory drug ketorolac. Thyroid 2008 18(12) 1285-90. 

Under similar conditions the reaction between pyrroles and enals affords C-2-alkylated products, giving access to a wide range of compounds of biological interest. This strategy was used in tandem with a ruthenium-mediated cross-metathesis reaction in the synthesis of a nonsteroidal anti-inflammatory drug (—)-ketorolac (eq 7). ... 

This last tyj of nonsteroidal anti-inflammatory drugs, such as ibuprofen ([rac-2-(4-iso-butylphenyl) propionic acid], 5), flurbiprofen ([rac-2-((3-fluoro-4-phenyl)phenyl)propionic acid], 6), fenoprofen ([rac-2-(3-phenoxyphenyl)propionic acid], 7), suprofen ([rac-2-(4(2-fliienyloxo)phenyl)propionic acid, 8], carprofen ([rac-2-(6-chloro-9H-cabazolyl) propionic acid], 9), naproxen ([5(+)-2-(6-methoxy-2-naphthyl)propionic acid], 10), Dexketoprofen ([S(+)-2-(3-benzoylphenyl)propionic acid], 11), flunoxaprofen ([S(+)-2-(2(4-fluoro-phenyl)benzoxazol-5-yl)propionic acid], 12), or ketorolac ([5(+)-5-benzoyl-2,3-dihidro-1/i-pyrrolizine-l-carboxylic acid], 13, thromethamine salt marketed as Toradol), have a more promising future. 

Analysis of non-steroidal anti-inflammatory drugs (ibuprofen, ketoprofen, naproxen, fenoprofen, flurbiproen, and suprofen) Impurity profiling of ketorolac, a chiral nonsteroidal antiinflammatory drug Impurity profiling of a non-steroidal analgesic drug... 

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