Ketoconazole Ethanol

The cytochrome P450 (CYP) system is the group of enzymes of most interest to psychiatrists. These enzymes show considerable genetic variation, and certain isozymes can be induced by specific substrates such as phenobarbital, ethanol, and steroids. They can also be inhibited by various medications that are potent competitive inhibitors of the enzymes (e.g., cimetidine and ketoconazole). 

Clinically important, potentially hazardous interactions with alcohol, cimetidine, CNS depressant, erythromycin, ethanol, ketoconazole, nefazodone, nelfinavir, olanzapine, rifampin, ritonavir, tricyclic antidepressants... 

Ketoconazole Antifungal Oleic acid, Ethanol, Cremophore EL, Transcutol, PEG 6000 7-fold AUC improvement as compared to suspension [95]... 

Magnasco AJ, Magnasco LD. Interaction of ketoconazole and ethanol. Clin Pharm (1986) 5, 522-3. 

Ketoconazole is a white to off-white crystalline powder. It is lipophilic with a reported logP value of 3.5. It is practically insoluble in water, sparingly soluble in ethanol, but soluble in methanol and methylene chloride. It should be protected from light. 

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