Kauradienoic acid

LOZOYA, X., ENRIQUEZ, R.G., BEJAR, E., ESTRADA, A.V., GIR6N, H PONCE-MONTER, H., GALLEGOS, A.J., The zoapatle V - the effect of kauradienoic acid upon uterine contractility., Contraception, 1983,27,267-279. 

Grandiflorenic (kauradienoic) acid (1) Kaurene diterpene Uterotonic, uterorelaxant, Ca " " channel blocker activity, antibiotic [31-35]... 

The kaurans present in M. tomentosa and M. frutescens have been extensively studied. This chemical group is relatively abundant in nature and arises by simple oxidation and/or epoxidation and hydrolysis reactions. They are precursors of giberellic acid and therefore have demonstrated activity as plant regulators [35]. The kaurenes have uterotonic and uterorelaxant effects but also display a wide spectrum of antimicrobial and fungicidal activities especially kauren-19-oic acid. Grandiflorenic acid (Kauradienoic acid, GA) is weakly active against Bacillus subtilis, and the methyl ester compounds appear to be less active [35]. 

Concerning the development of "zoapatle" as a contraceptive phytomedicine, limited attempts have been made to systematically demonstrate the presence of the different classes of compounds in the traditional decoction. So far, reports are conclusive only about the presence of kaurenic derivatives, kauradienoic acid, kaurenoic acid and monoginoic acid [45] and the oxepane tomexanthin [39]. Progress in analytical methods allows one today to carry out a complete HPLC profile of an aqueous plant extract. Thus, "zoapatle s" decoction should be analyzed again, using the 40 plus isolated compounds as standards. 

Figure 5 The FID time signal (A) and H frequency spectrum (B) for the aliphatic region of kauradienoic acid [1]. The scale along the bottom of the frequency spectrum is the 5 scale [chemical shift in parts per million relative to (CH3)4Si].

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