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Grandiflorenic acid

BEJAR, E., ENRIQUEZ, R., LOZOYA, X., The in vitro effect of grandiflorenic acid and zoapatle aqueous crude extract upon spontaneous contractility of the rat uterus during estrus cycle., J. Ethnopharmacol., 1984,11,87-97. [Pg.308]

The Kaurene Series.—The resin of Espeletia grandiflora contains (—)-kaurene, (-)-kaur-16-en-19-ol, the C-19 aldehyde and acid, as well as grandiflorolic acid [15a-hydroxy-( —)-kaur-16-en-19-oic acid] (70) and grandiflorenic acid [(-)-kaur-9(ll),16-dien-19-oic acid] (71). ( —)-Kaur-16-en-19-oic acid and 16a-kauran-19-oic acid, together with polyalthic acid and eperu-8(17)-en-15,18-dioic acid, have been isolated from Copaifera langsdorjii. The rhizome of the... [Pg.140]

The kaurans present in M. tomentosa and M. frutescens have been extensively studied. This chemical group is relatively abundant in nature and arises by simple oxidation and/or epoxidation and hydrolysis reactions. They are precursors of giberellic acid and therefore have demonstrated activity as plant regulators [35]. The kaurenes have uterotonic and uterorelaxant effects but also display a wide spectrum of antimicrobial and fungicidal activities especially kauren-19-oic acid. Grandiflorenic acid (Kauradienoic acid, GA) is weakly active against Bacillus subtilis, and the methyl ester compounds appear to be less active [35]. [Pg.811]

Fig. (4). The effects of grandiflorenic acid (GA) on the isolated rat uterus on different phases of the estrus cycle. Arrows indicate GA (40 M) addition. Fig. (4). The effects of grandiflorenic acid (GA) on the isolated rat uterus on different phases of the estrus cycle. Arrows indicate GA (40 M) addition.
Fig. (5). The effect of "zoapatle s brew" (ZACE), grandiflorenic acid (AC) and verapamil (Ve) on the responses elicited by oxytocin (OT), prostaglandin F2 alpha (PGp2a) and acetylcholine (Ach) on isolated rat uterus. Arrows indicate the additions of compounds. For detetils of the study see reference [33]. Fig. (5). The effect of "zoapatle s brew" (ZACE), grandiflorenic acid (AC) and verapamil (Ve) on the responses elicited by oxytocin (OT), prostaglandin F2 alpha (PGp2a) and acetylcholine (Ach) on isolated rat uterus. Arrows indicate the additions of compounds. For detetils of the study see reference [33].
Fig. (6). Effect of grandiflorenic acid (A) and its methyl ester (B) on the uterine smooth muscle of different animal species. C=guinea pig, R=rat and H=human. Details see paper [34],... Fig. (6). Effect of grandiflorenic acid (A) and its methyl ester (B) on the uterine smooth muscle of different animal species. C=guinea pig, R=rat and H=human. Details see paper [34],...
Enriquez RG, Escobar LI, Romero ML, Chavez MA et al. 1983 Determination of grandiflorenic acid in organic and aqueous extracts of Montanoa tomentosa (Zoapatle) by reversed-phase high-performance liquid chromatography. J Chromatogr 258 297-301... [Pg.1131]

Grandiflorenic (kauradienoic) acid (1) Kaurene diterpene Uterotonic, uterorelaxant, Ca " " channel blocker activity, antibiotic [31-35]... [Pg.807]

See other pages where Grandiflorenic acid is mentioned: [Pg.381]    [Pg.299]    [Pg.300]    [Pg.303]    [Pg.175]    [Pg.812]    [Pg.100]    [Pg.1092]    [Pg.1103]    [Pg.381]    [Pg.299]    [Pg.300]    [Pg.303]    [Pg.175]    [Pg.812]    [Pg.100]    [Pg.1092]    [Pg.1103]    [Pg.300]    [Pg.301]   
See also in sourсe #XX -- [ Pg.295 , Pg.299 ]

See also in sourсe #XX -- [ Pg.19 , Pg.389 ]

See also in sourсe #XX -- [ Pg.1092 , Pg.1103 ]



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