Kalihinenes Kalihinol

Kalihinols G (277) and H (278) were trace components of a species of Acanthella from Guam and kalihinol X (279) was isolated from a Fijian species of Acanthella. All inhibited growth of Bacillus subtilis, Staphylococcus aureus and Candida albicans [278]. 10-Epi-isokalihinol H (280) and 15-isothiocyanato-l-epi-kalihinene (281) were isolated from Acanthella cavernosa from the Seychelles [279]. A Japanese specimen of A. cavernosa contained a sesquiterpene isothiocyanate (282) and 10 3-formamido-5p-isothiocyanatokalihinol A (283). Structures were assigned by spectral data interpretation [280]. Phakellia pulcherrima from the Philippines contained the minor diterpene isothiocyanates kalihinol L (284), 10-isothiocyanatokalihinol G (285), 10-epi-kalihinol H (286) and 10-isothiocyanatokalihinol C (287) [281]. 10-Epi-kalihinol I (288) and 5,10-bisisothiocyanatokalihinol G (289) were isolated from an Acanthella sp. from Okinawa [282]. 

Kalihinol A (108) was originally isolated as an antimicrobial compound from Acanthella sp. collected in Guam. Kalihinol A, and other isocyanides, including kalihinenes X (166), Y (167), and Z (168), as well as 10-formamidokalihinene (169) — all of which were isolated from the Japanese Acanthella cavernosa—were shown to inhibit the larval settiement and metamorphosis at concentrations less than 0.1 pgmP whereas toxicity toward the barnacle cyprids was very low (LD50 values > lOOpgmP ). Antimalarial activity was also reported for other biological activities of kalihinol A. ... 

Rodriguez, J., Nieto, R.M., Hrmter, L.M., Diaz, M.C., Crews, P., Lobkovsky E., and Clardy, J. (1994) Variation among known kalihinol and new kalihinene diterpenes from the sponge Acanthella cavernosa. Tetrahedron, 50, 11079-11090. 

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