Kageneckia oblonga

Delporte et al. [13] isolated two cucurbitacins from Kageneckia oblonga using a complex method involving column chromatography on Amberlite, Sephadex LH-20, and MPLC. However, to separate the two major components of Cayaponia tayuya, Recio et al. [43] used a simple method based on gel-filtration through Sephadex LH-20 with dichloromethane as the mobile phase. 

From the anti-inflammatory, antipyretic, analgesic, and antioxidant extract of Kageneckia oblonga, Delporte et al. [13] isolated two cucurbitacins which were assayed as potential antioxidants and also as inhibitors of enzymes implicated in inflammatory reactions. Isolated compounds, 23,24-dihydrocucurbitacin F and 3P-( 3-D-glucosyloxy)-16a,23a-epoxy-cucurbitan-5,24-diene-ll-one, Fig. (11), inhibited the production of superoxide anion as well as elastase release in stimulated human neutrophils. In addition, the compounds inhibited both nitrite and... 

Fig. (11). Chemical structures of active cucurbitacins from Kageneckia oblonga...

Tn the case of the extract of Kageneckia oblonga, the authors established a relationship between cucurbitacins present in the extract and its antipyretic and analgesic activities, justifying a potential mechanism in which a decrease in PGE2 production through the inhibition of COX activity is implicated [13]. 

The methanol extract of Kageneckia oblonga showed a high cytotoxicity against P-388 murine leukemia, A-549 human lung... 

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