Isradipine Carbamazepine

FKiURE 6 5C. Efficacy of dihydropyridine L-type calcium channel blockers. Mean deviation from euthymia ratings (number of days in parentheses) in a patient with bipolar 11 disorder with ultra-ultrarapid cycling showing the following efficacy of nimodipine monotherapy efficacy of nimodipine-carbamazepine combination therapy unsuccessful transition from nimodipine to verapamil successful reinstitution of nimodipine-carbamazepine combination therapy and, finally, successful transition to isradipine-carbamazepine combination therapy. P <. 05 "nimodipine slowly tapered to zero. 

Feedback interference/lactose, sugar alcohols, H2 antagonists, carbamazepine, vidarabine, isradipine, dopaminergics, finasteride Feedback interference (proestrogens, finasteride, methoxychlor, cadmium) Feedback interference (proestrogens, dopamine agonists)... 

Carbamazepine Carbamazepine Carbamazepine Carbamazepine Carbamazepine + + + Verapamil Isradipine Isradipine... 

A 21-year-old white man, who was taking phenytoin and carbamazepine for seizures, developed severe lethargy, ataxia, and weakness after isradipine was prescribed for blood pressure control. The interaction was verified 2 months later, when he was rechallenged with the same dose of isradipine, 2.5 mg bd, and developed... 

Clinically important, potentially hazardous interactions with amlodipine, anisindione, anticoagulants, aprepitant, atorvastatin, barbiturates, benzodiazepines, butabarbital, carbamazepine, chlordiazepoxide, clarithromycin, clonazepam, dorazepate, corticosteroids, cyclosporine, dexamethasone, diazepam, dicumarol, erythromycin, ethotoin, felodipine, flurazepam, fluvastatin, fosphenytoin, isradipine, itraconazole, ketoconazole, lorazepam, lovastatin, mephenytoin, mephobarbital, midazolam, nicardipine, nifedipine, nimodipine, nisoldipine, oxazepam, pentobarbital, phenobarbital, pimozide, pravastatin, primidone, quazepam, rifampin, secobarbital, simvastatin, St John s wort, temazepam, warfarin... 

Both diltiazem and verapamil can increase serum carbamazepine levels causing toxicity. Limited evidence suggests that amlodipine and nifedipine do not affect carbamazepine levels. A single case report describes neurological toxicity in a patient taking phenytoin and carbamazepine with isradipine. 

A man taking carbamazepine and phenytoin developed neurological toxicity while taking isradipine, which was attributed to an interaction between the phenytoin and isradipine." However, although carbamazepine levels remained within normal limits, a commentator suggested that an interaction between carbamazepine and isradipine was plausible. ... 

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