Isotope effect studies deuterium

A. Carbon-14 and Deuterium Isotope Effect Studies of the Diels-Alder... 

Kopple K, Meyerstein D, Meisel D (1980) Mechanism of the catalytic hydrogen production by gold sols. Hydrogen/deuterium isotope effect studies. J Phys Chem 84 870-875... 

A methodology that has turned out to be a very powerful tool in trying to unravel the intricacies of the mechanism of cytochrome P450-catalyzed oxidation reactions has been the use of deuterium isotope effects. The use of intramolecular deuterium isotope effects have been particularly important in this regard as will be described in chapter 4 where a number of such studies are presented. But, before describing the specific technique that intramolecular isotope effect studies entail, a quick mini review on the nature of deuterium isotope effects is probably in order. 

Abstract A brief introduction deals with the time period from Dalton to the discovery of isotopes by Soddy and Fajans in the early twentieth century which was soon followed by the invention of the mass spectrograph (1922). The next section covers the period from 1922 to the discovery of deuterium by Urey and his colleagues. It includes a discussion of isotope effects in spectroscopy, particularly band spectra of diatomic molecules, and also discusses the discovery of the important stable isotopes in the second row of the periodic table. It ends with the discovery of deuterium, probably the most popular isotope for isotope effect studies. The chapter ends with a short description of the apparatus of theory and experimentation available for isotope effect work at the time of the discovery of deuterium. 

We will use reaction 10.15 to illustrate two important concepts of kinetic isotope effect studies. The first concerns the relation between isotope effects of different isotopes of the same element, say D and T. We denote the rate constant of reaction 10.15 by kn and consider isotope effects when one hydrogen in the a-position is substituted by deuterium or tritium ... 

Deuterium tracer and isotope effect study of Mn(lll)-based oxidative free-radical cyclizations... 

Deuterium isotope effect study of the metabolism of testosterone by CYP2C11... 

Deuterium and tritium isotope effect study of the methyl-methylene elimination in the enzyme catalyzed biosynthesis of (R)- and (S)- limonenes (506)... 

Brooks, H. B., Jones, L. H., and Davidson, V. L., 1993, Stopped-flow kinetic and deuterium kinetic isotope effect studies of the quinoprotein methylamine dehydrogenase from Paracoccus denitrificans. Biochemistry 32 272592729. 

Pompon, D., Iwatsubo, M., and Lederer, F., 1980, Flavocytochrome bz (bakeris yeast). Deuterium isotope effect studied by rapid kinetic methods as a probe for the mechanism of electron transfer, Eur. J. Biochem. 104 479M88. 

Keefer LK, Streeter AJ, Leung LY, et al. 1987. Pharmacokinetic and deuterium isotope effect studies on the metabolism of formaldehyde and formate to carbon dioxide in rats in vivo. Drug Metab Dispos 15 300-304. 

Warshel, a., Bromberg, A., Oxidation of 4a,4b-Dihydrophenanthrenes. III. A Theoretical Study of the Large Kinetic Isotope Effects of Deuterium in the Initiation Step of the Thermal Reaction With Oxygen, J. Chem. Phys. 1970, 52, 1262. 

Kinetic and deuterium isotope effect study of selective and total oxidation... 

To study the solvent-isotope effect of deuterium on binding and on the... 

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