Isosorbide dinitrate tablets

Oral 37.5 mg hydralazine + 20 mg isosorbide dinitrate tablets Inamrinone (generic)... [Pg.317]

Torok, I. Paal, T. Koszegine Szalai, H. Keseru, P. [High performance liquid chromatographic assay and determination of the even distribution of active ingredients in nitroglycerin and isosorbide dinitrate tablets]. Acta Pharm.Hung., 1985, 55, 154-162... [Pg.978]

The former group, where about 98-99% of the pure substance are contained in the sample, is rather inconvenient with respect to the 2 to 3% reproducibility of the method. In the following,(3rd Edition of PhBS III 1970 Pharmacopoea Bohemoslovenica, Editio tertia,) the polarographic determination of the content in pure substances disappeared. The most recent edition of the USP XX also contains articles with polarographic assays, e.g. in case of Phenylmercuric Nitrate, Thimerosal, Diluted Isosorbide Dinitrate, Isosorbide Dinitrate Tablets etc. (Moreover the USP XX contains an excellent general chapter on fundamentals of various polarographic methods),... [Pg.153]

Diluted Isosorbide Dinitrate Isosorbide Dinitrate Tablets Hethazolamide Tablets Nitrofurantoin Nitrofurantoin Tablets Nitrofurantoin Oral Suspension Procarbazine Hydrochloride Capsules... [Pg.165]

Isosorbide is rapidly absorbed and undergoes rapid first-pass metaboHsm by the Hver. The bioavaUabUity of the subHngual and chewable tablets is 59% and 22%, respectively, for the regular tablet. Isosorbide is metabolized to isosorbide-2-mononitrate and isosorbide-5-mononitrate, both of which have pharmacologic activity. The elimination half-Hves of subHngual and po isosorbide dinitrate ate 1 and 4 h, respectively. Those of the 2- and 5-mononitrate metaboHtes are 1.5—3.1 h and 4—5.6 h, respectively. The two metaboHtes prolong the elimination half-life of the dinitrate. Adverse effects with isosorbide are similar to those described for nitroglycerin (99). [Pg.125]

Direct Vasodilators Isosorbide dinitrate 20 mg and hydralazine 37.5 (BiDil) 1-2 tablets three times a day Minoxidil (Loniten) Hydralazine Heart failure (isosorbide dinitrate + hydralazine in African-Americans) A-HeFT66 Edema (minoxidil) Tachycardia Lupus-like syndrome (hydralazine) ... [Pg.20]

Isosorbide dinitrate slow-release capsules Isosorbide mononitrate tablets Isosorbide mononitrate 40 mg 1-2 times daily, with a daily nitrate-free interval of at least 18 hours 20 mg 2 times daily, with doses 7 hours apart 30-120 mg once daily... [Pg.78]

Cognate Assays The following two pharmaceutical products, namely Pentaerythritol tetranitrate Tablets and Diluted Isosorbide dinitrate are assayed by using a solution of phenoldisulphonic acid as detailed below ... [Pg.310]

A 58-year-old man with a history of angina for which he occasionally takes isosorbide dinitrate is having erectile dysfunction. He confides in a colleague who suggests that sildenafil might help and gives him three tablets from his own prescription. The potentially lethal combination of these drugs relates to... [Pg.140]

ACC/AHA guidelines (II), the combined use of hydralazine-isosorbide dinitrate may be considered as a therapeutic option in patients with reduced LV dysfunction already taking ACE inhibitors and (3 blockers and with persistent symptoms. Despite the lack of data about this vasodilator combination in patients who are intolerant of ACE inhibitors, the combined use of hydralazine and isosorbide dinitrate may be considered as an additive therapeutic option in such patients, However, compliance with this combination has generally been poor because of the large number of tablets required and the high incidence of adverse reactions. [Pg.459]

I. Torok, T. Paal, H. Koszegi Szalai, and P. Keseru, High-performance liquid chromatographic assay and content uniformity determination of nitroglycerin and isosorbide dinitrate in tablets, Acta Pharm. Hung., 55 154 (1985). [Pg.438]

NITRATES 1. ANALGESICS-nefopam 2. ANTIARRHYTHMICS -disopyramide, propafenone 3. ANTIDEPRESSANTS-TCAs 4. ANTI EMETICS-cydizine 5. ANTIHISTAMINES -chlorphenamine, cyproheptadine, hydroxyzine 6. ANTIMUSCARINICS -atropine, benzatropine, cydopentolate, dicydover-ine, flavoxate, homat-ropine, hyoscine, orphenadrine, oxybutynin, procyclidine, propantheline, tolterodine, trihexyphenidyl, tropicamide. 7. ANTI-PARKINSON S DRUGS-dopaminergics 8. ANTI-PSYCHOTICS - pheno-thiazines, clozapine, pimozide 9. MUSCLE RELAXANTS-baclofen 1. t risk of antimuscarinic side-effects when isosorbide dinitrate is co-administered with these drugs 2. 1 efficacy of sublingual nitrate tablets... [Pg.131]

TCAs NITRATES 1. t risk of antimuscarinic side-effects when isosorbide dinitrate is co-administered with TCAs 2. i efficacy of sublingual nitrate tablets with TCAs 1. Additive effect both of these drugs cause antimuscarinic side-effects 2. Antimuscarinic effects i saliva production, which i dissolution of the tablet 1. Warn patients of this additive effect 2. Consider changing the formulation to a sublingual nitrate spray... [Pg.190]

Isosorbide dinitrate is administered sublingually, in chewable tablets, in immediate release tablets, in sustained-released tablets, or in capsules. [Pg.315]

This agent is available in tablet form. It does not undergo significant first-pass metabolism and so has excellent bioavailability after oral administration. The mononitrate has a significantly longer tj 2 isosorbide dinitrate and has been formulated as a plain tablet and as a... [Pg.530]

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