2- Isopropyl-l-phenyl

Ethyl-l-methyl-l-phenyl- 328 2-Ethyl-2-methyl-l-phenyl- 1887 2-Ethyl-l-(4-melhyl-phenyl)- 334, 350 2-Isopropyl-l-phenyl 75,351,361,362, 363... 

N-Diphenylmethylen- 374 N-Diphenylmethylen-O-aminocarbonyl- 612 N-[l,3-Diphenyl-propyl-(2) - 374 N-[l,3-Diphenyl-propyliden-(2)]- 374, 377, 380 N-(4-Halogen-phenyI)- 683 N-Heptyl- 375 N-Heptyl-N-acetyl- 376 N-Heptyliden- 375 N-Hcptyliden-O-acetyl- 376 0-(2-Hydroxy-athyl)-N-athoxycarbonyl- 133 N-(4-Hydroxy-phenyl)- 683 0-(2-Hydroxy-l-phenyl-athyI)-N-athoxycarbonyI-aus 0-(ci-AthoxycarbonyI-benzyl)-N-athoxycar-bonyl-hydroxylamin und Lithiumalanat 133 N-Isopropyl- 682 N-Isopropylidcn- 613 N-Methyl- 133, 682 O-Methyl-N-bcnzyliden- 377 O-Methyl-N-benzyliden- 375 0-Methyl-N-(4-chlor-benzyl)- 375 0-Methyl-N-(4-chlor-benzyliden)- 375 N-Methy -N,0-diacetyI- 682 N-(4-Methyl-phenyl)- 683 0-McthyI-N-( 1 -phenyl-athyliden)- 375 N-(4-Methylthio-phenyl)- 684 N-(4-Nitro-benzyl)- 374 N-[4-Nitro-benzyliden - 374, 377 N-(2-Nitro-phenyl)- 562 N-(4-Nitro-phenyl)- 682 N-Nitroso-N-cyclohexyl- 697 N-Octyl- 374 N-Octyl-(2)-N-acetyl- 376 N-Octyliden- 374 N-0ctyliden-(2)-0-acctyl- 376 N-(Pentafluor-phenyl)-0,N-diacetyl- 697 N-Phenyl- 474, 481, 682, 783 N-Phenylacetyl-O-benzoyl- 265 N-(l-Phenyl-athyl)- 374 N-(l-Phenyl-athyl)-N-acetyl- 376 N-(l-Phenyl-athyliden)-374, 613 N-( l-Phenyl-athyliden)-0-acetyl- 376 N-[ 1 -Phenyl-buten-( 1 )-yl-(3)-iden]- 582 N-f4-Phenyl-butyl-(2)-iden]- 581 N-Phcnyl-N,0-diacetyl- 682 N-(4-Phenylthio-phenyl)- 684 N-Propyl-N-cyclohexyl- 376 N-Propyl-N-isopropyl- 376 O-Sulfonyl- 481 N-(4-Sulfonyl-phenyI)- 683 N-(2-Vinyl-phenyl)- 698... 

It has not yet been determined which structure [3] or [3 ] the triazoline has. The reaction mechanism of triazoline formation proposed by P.Scheiner, suggests that the structure may be 5-isopropyl-l-phenyl-A -i,3-triazoline(structure[3]). This conclusion was also supported by the fact that 3-methy 1-2-butylidene-aniline[5] was obtained by the decomposition of the triazoline (vide infra). 

Figure 2. IR spectrum of 5-isopropyl-l-phenyl-A2-l,2,3-triazoline and its change...

Cyclopropan 3-(3,4-Dichlor-phenyl)-2-isopropyl-l-methyl- E17a, 340 (Ar—CHN2 + En)... 

Isopropyl-l-[2-(l-phenyl-elhyl)-hy-drazinocarboiiyl]- 1876 2-[2-(l-Phenyl-ethyl)-hydrazinocar-bonyl]-l-propyl- 1876... 

Chloro-l,l-dimethyl- 536 2-Chloro-l-isopropyl- 536 2-Chloro-l-methyl- 536 2-Chloro-l-phenyl- 536... 

Sterically hindered, 2-alkyl-substituted dienes form high 1,4 microstructure in polar media as well as in hydrocarbon media (115). Butyllithium-initiated polymerization of 2-isopropyl-l,3-butadiene in diethyl ether produces a polymer with 81% cis-1,4 and 19% trans-1,4 microstructure. Similarly, >90% 1,4 microstructure is observed in THF for butyllithium-initiated polymerization of 2-triethylsilyl-l,3-butadiene, 2-trimethoxysilyl-l,3-butadiene, l-phenyl-l,3-butadiene,l-pyridyl-l,3-butadiene, and 2-phenyl-l,3-butadiene. 

Indazole, 5,5-dimethyl-3-trifluoromethyl-4,5-dihydro-trichomonacidal activity, 5, 291 Indazole, 2-ethoxycarbonyl-reactions, 5, 269 Indazole, 3-fluoro-synthesis, S, 263 Indazole, 1-germyl-synthesis, 5, 236 Indazole, 1-glycosyl-synthesis, 5, 289 Indazole, 2-glycosyl-synthesis, 5, 289 Indazole, halo-reactions, S, 266 Indazole, 2-hydroxy-methylation, 5, 269 Indazole, 3-hydroxy-reactions, S, 264 Indazole, 6-hydroxy-diazo coupling, 5, 86 Indazole, hydroxyphenyl-synthesis, S, 288 Indazole, 3-iodo-synthesis, S, 241 Indazole, l-isopropyl-3-phenyl-reduction, 5, 243 Indazole, 3-mercapto-1 -substituted tautomerism, 5, 265 Indazole, methoxy-... 

Replacement of one of the phenyl groups by an alkyl group of similar bulk, on the other hand, alters the biologic activity in this series. Alkylation of phenylacetonitrile with isopropyl bromide affords the substituted nitrile, 136. Treatment of the anion prepared from 136 with strong base with 2-dimethylamino-l-chloropropane gives isoaminile (137). It is of note that alkylation of this halide, isomeric with that used in the early methadone synthesis, is apparently unaccompanied by isomer formation. Isoaminile is an agent with antitussive activity. 

V-[2-(3-Phenylprop-2-ynyloxy)benzylidene]isopropylamine (the structure in ref 95 is incorrect) undergoes a cyclization reaction to A -isopropyl-4-phenyl-l-benzoxepin-5-amine (1, 52% yield) when treated with butyllithium. 2-(Phenylethynyl)benzofuranis formed as a byproduct (4%).95... 

The aldol reaction of 2,2-dimethyl-3-pentanone, which is mediated by chiral lithium amide bases, is another route for the formation of nonracemic aldols. Indeed, (lS,2S)-l-hydroxy-2,4,4-trimethyl-l-phenyl-3-pentanone (21) is obtained in 68% ee, if the chiral lithiated amide (/ )-A-isopropyl-n-lithio-2-methoxy-l-phenylethanamine is used in order to chelate the (Z)-lithium cnolate, and which thus promotes the addition to benzaldehyde in an enantioselective manner. No anti-adduct is formed25. 

Phenyl- -hydroximid-chlorid 354 Phenyl- -l-hydroxy-butyl-(2)-amid 24l Phenyl- -menthylester 606 Phenyl- -(5-methyI-2-isopropyl-cyclohexylester) 319... 

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