Isopropoxy methoxy

Relatively few studies have dealt with the reactions of primary and secondary aikoxy radicals (isopropoxy, methoxy, etc.) with monomers. These radicals are conveniently generated from the corresponding hyponitrites (Scheme 3.77).1"3 402... 

The six coordinated titanium(IV) compounds, Ti(acac)2(X)2, where X is methoxy, ethoxy, isopropoxy, -butoxy, or chloro, all adopt the cis-configuration. This is beheved to result from the ligand-to-metal TT-electron donation (88,89). 

Quinoxalinyl, 4-cinnolinyl, and 1-phthalazinyl derivatives, which are all activated by a combination of induction and resonance, have very similar kinetic characteristics (Table XV, p. 352) in ethoxylation and piperidination, but 2-chloroquinoxaline is stated (no data) to be more slowly phenoxylated. In nucleophilic substitution of methoxy groups with ethoxy or isopropoxy groups, the quinoxaline compound is less reactive than the cinnoline and phthalazine derivatives and more reactive than the quinoline and isoquinoline analogs. 2-Chloroquinoxaline is more reactive than its monocyclic analog, 2-chloropyrazine, with thiourea or with piperidine (Scheme VI, p. 350). 

In contrast to the 3-methoxy derivative (see Section 3.2.2.5.3.), the 3-isopropoxy-l//-2-benz-azepine 1 on treatment with sodium propan-2-olate undergoes dehydrobromination to the propenyl derivative 2.80... 

As predicted, the C2,C2 -isopropoxy and propoxy groups are more potent than the corresponding methoxy (0.8 and 1.5 pM vs. 6.4 pM). In addition, C3,C3 -substitution has an effect on both the potency and photopotentiation factor. Although the absorption at 670 nm was improved with C3 substitution, the potency against PKC decreased for analogs 90, 92, and 97. 

In the third series, 1-methoxy-, 1-ethoxy-, 1-isopropoxy-, 1-tertbutoxy- and l-(chloromethyl)silatranes were examined in comparison with well-known preparations widely used in therapy such as Vishnevsky ointment, synthomicyn emulsion, and cygerol (Table 14),... 

Allyl-l-(allyloxymethyl)-3-isopropoxy-4-methoxybenzene 149 can undergo a one-pot ruthenium catalyzed isomerization followed by RCM in the presence of Grubbs second generation catalyst 37 to afford 5-isopropoxy-6-methoxy-1 //-isochromcnc (Scheme 48) <2003SL1859>. 

Hexaphenyl-2,6-naphthyridine 3-Hexyl-2,6-naphthyridine 3-Hexyl-2,6-naphthyridine 2-oxide 3-Hydroxy-2,6-naphthyridin-1 (2//)-one l-Isopropoxy-2,6-naphthyridi n-3-amine 3-Isopropoxy-2,6-naphthyridi n-1 -amine l-Isopropylamino-2,6-naphthyridin-3-amine l-Methoxy-4-methyl-2,6-naphthyridin-3-amine l-Methoxy-2,6-naphthyridin-3-amine... 

In mixed acetals the identities of the carbon-alkoxy bond cleaved or retained are a synthetically important issue. Equations (58) [177,178] and (59) [179] illustrate discrimination between oxy groups. In the former the isopropoxy group more accessible to the Lewis acid seems to be eliminated whereas in the latter reaction, a better leaving group, the hydrogen peroxide anion, is eliminated and, at the same time, the more cation-stabilizing methoxy group remains in the product. 

Pyrolyses and thermal stabilities of 2-hydroxy-, 2-ethoxy-, and 2-isopropoxy-pyrazines have been studied. 2-Hydroxypyrazine was very stable, but the alkoxy-pyrazines underwent thermal elimination of olefin to yield 2-hydroxypyrazine (668a). Electrochemical reductions of l-methyl-2-oxo-5,6-diphenyl-l,2-dihydro-pyrazine and 54iydroxy(and 5-methoxy)-2,3-diphenylpyrazine are reported to involve the intermediate enamine, for example, 6-hydroxy-1-methyl-2,3-diphenyl-1,4-dihydropyrazine (54) (1096, cf. 1097). When tested on mice 2-carbamoyl-5-methoxypyrazine had less anti tubercular activity than did pyrazinamide (1098). 

Carbamoy 1-2-hydroxy-5 -phenyl 2-Carbamoyl-6-isopropoxy 2-Carbamoyl-3-methoxy 2-Carbamoyl-5( )-methoxy 2-Carbamoyl-6-methoxy... 

Carboxy-2-hydroxy-5-phenyl 2-Carboxy-6-isopropoxy 2-Carboxy-3-methoxy 2-Carboxy-5-methoxy 2-Carboxy-6-methoxy... 

In addition, VTMS hydrolyzes to a much eater extent than MTMS, an expected pattern similar to the /sopropoxy examples. Clearly the bulk of the Mopropoxy groups on the hindered silanes is very beneficial in protecting the silane from premature reaction during latex polymerization, when compared to the more traditional methoxy substituted silane monomers. This has implications for the ultimate properties of the final films, as the stability of the isopropoxy silanes allows levels of incorporation, and thus final performance, that are sinq)ly not available when using methoxy-substituted silane monomers. 

The bulk of the isopropoxy groups on the vinyl and methacryl silanes is unique among silane monomers in that, through their enhanced stability, levels of incorporation of silane an order of magnitude greater than standard methoxy-substituted monomers is possible. Thus, much higher performance can be achieved using these silane monomers. 

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