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Isoniazid gastrointestinal effects

D. Enhancement of Elimination Enhancement of elimination is possible for a number of toxins, including manipulation of urine pH to accelerate renal excretion of weak acids and bases. For example, alkaline diuresis is effective in toxicity due to fluoride, isoniazid, fluoroquinolones, phenobarbital, and salicylates. Urinary acidiflcation may be useful in toxicity due to weak bases, including amphetamines, nicotine, and phencyclidine, but care must be taken to avoid acidosis and renal failure in rhabdomyolysis. Hemodialysis or hemoperfusion enhances the elimination of many toxic compounds, including acetaminophen, ethylene glycol, formaldehyde, lithium, methanol, procainamide, quinidine, salicylates, and theophylline. Cathartics such as sorbitol (70%) may decrease absorption and hasten removal of toxins from the gastrointestinal tract. [Pg.520]

HurwitzA, SchlozmanDL. Effects of antacids on gastrointestinal absorption of isoniazid in rat and man. AmRevRespirDis 91A) 109, 41-7,... [Pg.308]

Rifampicin toxicity is becoming of greater importance in the treatment of leprosy. Several studies have recently been reported in which rifampicin was used in combination with Isoprodian, a combination of dapsone, isoniazid and prothionamide. The commonest adverse effects observed on this combination are gastrointestinal disturbances and mild hepatitis, manifested either as abnormalities in biochemical parameters or clinically by jaundice. One case of exfoliative dermatitis was reported from a trial carried out in South India (35 ). [Pg.233]


See other pages where Isoniazid gastrointestinal effects is mentioned: [Pg.559]    [Pg.510]    [Pg.1924]    [Pg.1925]    [Pg.1925]    [Pg.1929]    [Pg.3041]    [Pg.200]    [Pg.621]    [Pg.2028]    [Pg.197]    [Pg.786]    [Pg.555]    [Pg.234]   
See also in sourсe #XX -- [ Pg.606 ]




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