Isoeugenol, vanillin synthesis

The classical synthesis of vanillin from eugenol or isoeugenol was developed in 1896 and it remained the preferred method for about 50 years. Vanillin is now prepared industrially in large amounts by the Reimer-Tiemann reaction, starting with... 

During the first half of the nineteenth century, the importance of the single odorous chemicals contained in natural products was recognized, and efforts were devoted to their isolation and characterization. Soon after, their synthesis was carried out by chemical methods. Cinnamaldehyde was first isolated in 1834 and then synthesized in 1856 by Chiozza [2]. In 1874, Hemann and Haarmann deduced the chemical structure of vanillin, and found a synthesis from coniferin, a glucoside of isoeugenol found in pine bark [3]. In 1876, Reimer prepared vanillin from guaiacol [4, 5]. 

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