Pulmonary routes, irritation testing

Studies on test animals indicate that methylene bis(4-cyclohexylisocyanate) is highly toxic by an inhalation route and can cause severe skin reaction. Exposure to 20 ppm for 5 hours produced irritation of the respiratory tract, tremor, convulsion, congestion of lungs, and edema in rats. The symptoms at lower levels were decreased as to respiration rate and pulmonary irritation. 

Hydrogen Chloride (Anhydrous) - HCl, 7647-01-0 nonflammable, toxic gas by aU routes of exposure and intake bp -84.8 C [-121 F] er = NA sp g = 1.27 OSHA ceiling PEL = 5 ppm. Gas combines with moisture to become corrosive to eyes, skin, and respiratory system. Baseline physical exam should stress respiratory system, eyes, and skin. Pulmonary test and chest X-ray recommended. E q)osure to airborne concentrations above 1500 ppm can be fatal in a few minutes. Irritating properties detectable at about PEL. Should only be used in an efficient fume hood. Workers should wear gas-tight goggles, acid, resistant aprons, gloves, and outerwear. 

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