Irritant eugenol

Health and Safety. FEMA has examined cinnamaldehyde and estabhshed its GRAS status (No. 2286). The material has been used in some fragrance compositions, but RJEM (34) has noted its potential for sensiti2ation and limited the use in perfumes for skin contact at 1% in the formula. Eugenol and limonene have been used in conjunction with cinnamaldehyde as quenchers to neutrali2e the irritation reaction that some individuals have toward this aldehyde. 

Clove oil is used due to the presence of eugenol as its main constituent. It acts by paralysing the sensory never endings. It is non-irritating but stains the dentine yellow. 

Geum aleppicum Jacq. China Flavones, fatty acids, eugenol, gein, geoside.48 Treat bleeding, bug bite, convulsive disorder, fevers, irritability, obstinate skin diseases. 

N.A. Geum urbanum L. Phenolic glycosides (eugenol), tannins, volatile oil, sesquiterpene lactone, cnicin." Treat mouth, throat, and gastrointestinal tract disorders. For peptic ulcers, irritable bowel syndromes. 

SAFETY PROFILE Confirmed carcinogen. Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. A skin irritant. Mutation data reported. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes. Some other alkenylbenzenes have carcinogenic activity. See also EUGENOL, ALLYL COMPOUNDS, and ETHERS. 

SAFETY PROFILE Moderately toxic by ingestion. A severe skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes. See also EUGENOL. 

A. Inhalation. Vapors of phenol may cause respiratory tract irritation and chemical pneumonia. Smoking of clove cigarettes (clove oil contains the phenol derivative eugenol) may cause severe tracheobronchitis. 

Eugenol, which can be isolated from the flower buds (cloves) of Eugenia aromatica, is used as a dental antiseptic and analgesic. Urushiol is the main component in the irritating oil of poison ivy. 

Methylchavicol is the major constituent of oil of basil—Ocimum basilicum (Lamiaceae). As with other phenols this one is a skin irritant, though it is milder than eugenol—a component of the French basil varieties (Home and Williams 1990). 

Essential oils comprised of 10 g/L solutions of cedarwood, cinnamon, sage, juniper berry, lavender, and rosemary all of these were potent snake irritants. Brown tree snakes exposed to a 2 s burst of aerosol of these oils exhibited prolonged, violent undirected locomotory behavior. In contrast, exposure to a 10 g/L concentration of ginger oil aerosol caused snakes to locomote, but in a deliberate, directed manner. The 10 g/L solutions delivered as aerosols of m-anisaldehyde, frani -anethole, l,8-cineole, cinnamaldehyde, citral, ethyl phenylacetate, eugenol, geranyl acetate, or methyl salicylate acted as potent irritants for brown tree snakes Boiga irregularly (Clark and Shivik, 2002). 

Clove oil is reported to cause skin irritation and sensitization in humans. Despite its possible toxicity in high dosage levels, eugenol (and presumably cloves and clove derivatives) is considered nontoxic at normal use levels. ... 

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