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Irritancy isoniazid

A. Ethambutol is associated with retrobulbar neuritis, resulting in loss of central vision and impaired red-green discrimination. Ethionamide (B) is an analogue of isonicotinic acid and is associated with GI intolerance and peripheral neuropathy, but not the optic neuritis or color vision discrimination problems. Aminosalicylic acid (C) can cause GI irritation and bleeding problems, so caution is required in peptic ulcer patients. It has no neurological side effects. Rifampin (D) is associated with red-orange discoloration of saliva, tears, and urine but not the color vision problems. Isoniazid (E) is associated with peripheral neuritis in chronic alcoholics and malnourished individuals and requires pyridoxine supplements. It is not associated with optic neuritis. [Pg.565]

Ethionamide This structural analog of isoniazid is believed not to act by the same mechanism. It is effective after oral administration, and is widely distributed throughout the body, including the CSF. Metabolism is extensive. Ethionamide [e thye on AM ide] can inhibit acetylation of isoniazid (Figure 33.7). The urine is the main route of excretion. Adverse effects that limit its use include gastric irritation, hepatotoxicity, peripheral neuropathies, and optic neuritis. Isoniazid... [Pg.346]

In seven patients taking isoniazid 0.6-1.0 g/day for at least 1 month, disulfiram 0.5 g/day caused dizziness, disorientation, staggering, insomnia, irritability, listlessness, lethargy, and in one case hypomania (55). This interaction may have been due to inhibition of isoniazid metabolism by disulfiram or to a complex interaction with dopamine metabolism. [Pg.1927]


See other pages where Irritancy isoniazid is mentioned: [Pg.319]    [Pg.319]    [Pg.230]    [Pg.197]    [Pg.81]    [Pg.685]    [Pg.319]    [Pg.169]    [Pg.308]   
See also in sourсe #XX -- [ Pg.551 , Pg.557 ]




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Isoniazid

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