Iron oxide, saccharated

Iron oxide, saccharated (see Saccharated iron oxide)... 

SYNS COLLIRON I.V. n FEOJECTIN FERRIC OXIDE, SACCHARATED FERRIC SACCHARATE IRON OXIDE (MIX.) FERRIVENIN IRON SACCHARATE IRON SUGAR IVIRON NEO-FERRUxM PROFERRIN SACCHARATED FERRIC OXIDE SACCHARATED IRON SUCROFER... 

Other iron compounds for intravenous use Saccharated iron oxide is strongly alkaline and hypertonic if injected outside the vein it can cause marked local reactions. Significant serum hypophosphatemia has on occasion been observed during treatment, accompanied by reduced renal tubular reabsorption of phosphate. The mechanism of these changes, which were reversible after stopping the iron injections, has not been clarified (13). 

The parenteral iron medications available include iron dextran (ferric hydroxide and high-molecular-weight dextran) for intramuscular use, dextriferron (a complex of ferric hydroxide and partially hydrolyzed dextran) for intravenous use, and saccharated iron oxide (a complex of ferric hydroxide and sucrose) for intravenous use. These preparations are reserved for those cases in which oral preparations are not tolerated, absorbed, or rapid enough in their onset of action, or are otherwise not suitable for noncompfiant patients. 

Ferric Oxide, Saccharated, Saccharated iron iron sugar Colliron I.V. Feojectin Ferrivenini Ferum Ha us -mann Iviron Neo-Ferrum Proferrin Sucroler. Contains 2.8 -3.2% Fe. Prepn U.S.D. 26th ed, p 627 (1967). Prepn of soln corns 2% Fe suitable for i.v. injection Slack, Wilkinson, Lancet 256, 11 (1949). 

Saccharated iron oxide premedication modified the response of the reticulo-endotheUal cells in the fiver and spleen of the rabbit. There was a decrease in the proliferative response (Moore and Schoenberg 1963). 

Preparations of saccharated iron oxide suitable for intravenous injection are now available, and as a means of by-passing the barrier of regulated absorption and getting quick results their use is increasing, but as this... 

Eisen-wasser, n. chalybeate water, -wein, m. Pharm.) iron wine, -weinstein, m. Pharm.) iron and potassium tartrate, tartrated iron, -werk, n. ironworks, iron mill, -wolfram, n. ferrotungsten. -zeit, /. iron age. -zement, m. n. ferroconcrete, -zinkblende, /. mar-matite. -zinkspat, m. ferruginous calamine, -zinnerz, n. ferriferous cassiterite. -zucker, m. Pharm.) saccharated ferric oxide, -zuk-kersinip, m. Pharm.) sirup of ferric oxide. 

Oxidative stress and inflammation are elevated in hemodialysis patients, which, at least partly, might be initiated by intravenous iron administration. Thus, Tovbin et al. [377] showed that the administration of iron saccharide to hemodialysis patients increased the blood level of oxidized proteins. Similarly, an increase in the levels of free ( nontransferrin-bound or labile ) iron has been shown in the plasma of hemodialysis patients [378] including patients after intravenous iron saccharate infusion [379]. 

Colloidal saccharated iron is sometimes used in place of ferric hydroxide as an antidote in arsenical poisoning, but its adsorptive capacity depends on the alkalinity of the medium.4 Thus a commercial preparation containing 0-75 per cent, of sodium hydroxide was found to adsorb 12-57 per cent, of arsenious oxide (reckoned on the amount of iron present) addition of alkali increased the adsorption until, with 1-28 per cent, of sodium hydroxide present, there was a maximum adsorption of 27 per cent. The addition of acid correspondingly diminished the adsorption. A gel of ferric magnesium hydroxide, if prepared without boiling, also adsorbs arsenic from sodium arsenite solutions.5... 

Saccharated ferric oxide, an intravenous formulation of iron that is used when oral iron is not effective in anemia, can cause osteomalacia during long-term use. The underlying mechanism of nephropathy leading to bone toxicity has recently been reviewed (34). 

Sato K, Shiraki M. Saccharated ferric oxide-induced osteomalacia in Japan iron-induced osteopathy due to nephropathy. Endocr J 1998 45(4) 431-9. 

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