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Iron chelating agents for,

Brittenham GM (1992) Development of iron-chelating agents for clinical use. Blood... [Pg.325]

In the case of hemochromatosis, excess iron can be removed from patients bodies by venesection. On the other hand, removal of iron using an iron chelator is the only effective way to relieve iron overload in patients with y0-thalasemia or sickle cell anemia [52,53]. Neither of these therapies are optimum for the treatment of these diseases. The current standard of care for iron chelation therapy is desferrioxamine (Scheme 7), which is the only approved iron chelator for the treatment of iron overload conditions in the USA. Desferrioxamine has reportedly been associated with several drawbacks. It has a narrow therapeutic window and due to lack of oral bioavailability, it requires administration for 8-12 h per day by parenteral infusions [54]. Thus, there is a clear need for the discovery and development of a new generation of orally active iron-chelating agents for the treatment of iron overload conditions. [Pg.22]

Uses Stabilizer, sequestrant, dispersant, iron chelating agent for hydrogen peroxide bleach baths, for exhaust and continuous applies. controls oxidation to prevent damage which can cause yarn/fabric tendering, discoloration, and dyeing problems sequestrant, dispersant controlling Ca/Mg hardness and silicate... [Pg.1352]

Uses Dispersant, iron chelating agent for peroxide bleaching and scouring Features Minimizes buildup from hardness and silicates highly caustic stable improves fabric clean up in caustic treatments reduces redeposition of removed contaminants onto fabric and machinery... [Pg.1572]


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