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Iron-catalyzed Cyclopropane Formation

Acid-catalyzed dealkoxylation is particularly suitable for the preparation of highly reactive, cationic iron(IV) carbene complexes, which can be used for the cyclopropanation of alkenes [438] (Figure 3.11). Several reagents can be used to catalyze alkoxide abstraction these include tetrafluoroboric acid [457-459], trifluoroacetic acid [443,460], gaseous hydrogen chloride [452,461], trityl salts [434], or trimethylsilyl triflate [24,104,434,441,442,460], In the case of oxidizing acids (e.g. trityl salts) hydride abstraction can compete efficiently with alkoxide abstraction and lead to the formation of alkoxycarbene complexes [178,462] (see Section 2.1.7). [Pg.85]

A carbene or nitrene transfer reaction to a carbon-carbon or carbon-heteroatom double bond system leads to the formation of three-membered rings, such as a cyclopropane, an aziridine or an epoxide. These processes can be catalyzed by applying iron catalysts and the different cyclic systems are discussed here. [Pg.249]

The four-coordinate sqnare planar iron(n) porphyrins discussed above are not only of great valne in heme protein model chemistry, but also in chemical applications, since they undergo a wealth of ligand addition reactions. For example it has been shown that TPPFe complexes are active catalysts for important carbon transfer reactions in organic chemistry and are found to catalyze the stereoselective cyclopropanation of aUcenes, olefin formation from diazoalkanes, and the efficient and selective olefination of aldehydes and other carbonyl compounds. The active species in these carbon transfer reactions are presumably iron porphyrin carbene complexes. " It was also found that ferrous hemin anchored to Ti02 thin films reduce organic halides, which can pose serious health problems and are of considerable environmental concern because of their prevalence in groundwater. ... [Pg.2114]


See other pages where Iron-catalyzed Cyclopropane Formation is mentioned: [Pg.252]    [Pg.252]    [Pg.105]    [Pg.2186]    [Pg.2113]    [Pg.2185]   


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