IRAK Family

IRAK Family Iron Chelator Irreversible Antagonists Irritable Bowel Syndrome (DBS)... 

IL-1 receptor associated kinase family-A with Toll-like receptor signalling. There are four members in this group to date IRAK-1,2,4 and M. They can phosphor-ylate among themselves, as well with other proteins involved in signalling such as TRAF-6. 

Muzio M, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997 278 1612. 

In contrast to the shared receptor binding specificity among TRAFl, 2, 3, and 5, TRAF6 has a unique receptor interaction specificity that is not shared by other members of the TRAF family. In addition, TRAF6 is the only TRAF family member that also participates in the signal transduction of the IL-IR/TLR superfamily by its specificity for IRAKs. 

This receptor family mediates the effects of interleukin 1, a major proinflammatory cytokine, and interleukin 18, and includes TLR receptors of macrophages like TLR2 which recognize peptigoglycans of gram-positive bacteria. These receptors are coupled to the cytosohc serine/threonine kinase IRAK (interleukin receptor-associated kinase). Following signals include the activation of transcription factors like NFk,B, or others via MAP kinases. 

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